Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50448699 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1297892 (CHEMBL3132105) | ||
IC50 | 23±n/a nM | ||
Citation | Goldberg, FW; Dossetter, AG; Scott, JS; Robb, GR; Boyd, S; Groombridge, SD; Kemmitt, PD; Sjögren, T; Gutierrez, PM; deSchoolmeester, J; Swales, JG; Turnbull, AV; Wild, MJ Optimization of brain penetrant 11ß-hydroxysteroid dehydrogenase type I inhibitors and in vivo testing in diet-induced obese mice. J Med Chem57:970-86 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32369.70 | ||
Organism: | Mus musculus (mouse) | ||
Description: | P50172 | ||
Residue: | 292 | ||
Sequence: |
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BDBM50448699 | |||
n/a | |||
Name | BDBM50448699 | ||
Synonyms: | CHEMBL3127863 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H28N2O4S | ||
Mol. Mass. | 392.512 | ||
SMILES | COCCOc1nc(C2CC2)c(s1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:23.26,wD:16.17,TLB:15:16:20:22.23.25,26:23:16.17.18:20,THB:26:17:20:22.23.25,25:23:16:18.19.20,25:19:16:22.26.23,24:23:16:18.19.20,24:23:16.17.18:20,(21.81,-7.27,;23.26,-7.77,;24.42,-6.76,;25.88,-7.26,;27.04,-6.24,;28.5,-6.74,;28.95,-8.22,;30.49,-8.24,;31.38,-9.49,;31.52,-11.03,;32.78,-10.14,;30.99,-6.78,;29.76,-5.86,;32.32,-6.01,;32.31,-4.47,;33.66,-6.77,;34.99,-6,;36.49,-5.61,;36.51,-4.02,;37.57,-2.8,;36.22,-3.26,;36.2,-4.75,;37.52,-5.26,;38.93,-4.94,;40.47,-4.9,;38.96,-3.41,;37.89,-6.2,)| | ||
Structure |