Reaction Details |
| Report a problem with these data |
Target | Serine/threonine-protein kinase PAK 3 |
---|
Ligand | BDBM50448771 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1294406 (CHEMBL3129191) |
---|
IC50 | >10000±n/a nM |
---|
Citation | Staben, ST; Feng, JA; Lyle, K; Belvin, M; Boggs, J; Burch, JD; Chua, CC; Cui, H; DiPasquale, AG; Friedman, LS; Heise, C; Koeppen, H; Kotey, A; Mintzer, R; Oh, A; Roberts, DA; Rouge, L; Rudolph, J; Tam, C; Wang, W; Xiao, Y; Young, A; Zhang, Y; Hoeflich, KP Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type I 1/2 kinase inhibitors. J Med Chem57:1033-45 (2014) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Serine/threonine-protein kinase PAK 3 |
---|
Name: | Serine/threonine-protein kinase PAK 3 |
Synonyms: | OPHN3 | PAK3 | PAK3_HUMAN | Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 | Serine/threonine-protein kinase PAK 3 | p21-Activated kinase 3 (PAK3) |
Type: | Enzyme |
Mol. Mass.: | 62298.33 |
Organism: | Homo sapiens (Human) |
Description: | O75914 |
Residue: | 559 |
Sequence: | MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTN
KKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTS
NITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPP
LAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSA
ENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTA
LDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL
AGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTD
FGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE
NPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPL
SSLTPLIIAAKEAIKNSSR
|
|
|
BDBM50448771 |
---|
n/a |
---|
Name | BDBM50448771 |
Synonyms: | CHEMBL3128042 |
Type | Small organic molecule |
Emp. Form. | C22H26N6O2 |
Mol. Mass. | 406.4808 |
SMILES | COCCNc1nc2ccc(cc2n1-c1ccnc(N)n1)C#CC1(O)CCCCC1 |
Structure |
|