| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
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| Ligand | BDBM50379337 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1297372 (CHEMBL3132512) |
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| IC50 | 2790±n/a nM |
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| Citation |  Johannes, JW; Chuaqui, C; Cowen, S; Devereaux, E; Gingipalli, L; Molina, A; Wang, T; Whitston, D; Wu, X; Zhang, HJ; Zinda, M Discovery of 6-aryl-azabenzimidaoles that inhibit the TBK1/IKK-e kinases. Bioorg Med Chem Lett24:1138-43 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 2 |
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| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| BDBM50379337 |
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| n/a |
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| Name | BDBM50379337 |
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| Synonyms: | CHEMBL2011936 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26BrN5O2 |
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| Mol. Mass. | 472.378 |
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| SMILES | COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(=O)C3CCCC3)c2[nH]1 |
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| Structure | 
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