Reaction Details |
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Target | Vasopressin V2 receptor |
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Ligand | BDBM50416840 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_321075 (CHEMBL885140) |
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Ki | <79433±n/a nM |
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Citation | Borthwick, AD; Davies, DE; Exall, AM; Livermore, DG; Sollis, SL; Nerozzi, F; Allen, MJ; Perren, M; Shabbir, SS; Woollard, PM; Wyatt, PG 2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 2. Synthesis, chirality, and pharmacokinetics. J Med Chem48:6956-69 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Vasopressin V2 receptor |
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Name: | Vasopressin V2 receptor |
Synonyms: | ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor |
Type: | Receptor |
Mol. Mass.: | 40295.28 |
Organism: | Homo sapiens (Human) |
Description: | P30518 |
Residue: | 371 |
Sequence: | MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLA
ALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQM
VGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQ
RNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGP
SERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA
PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTT
ASSSLAKDTSS
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BDBM50416840 |
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n/a |
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Name | BDBM50416840 |
Synonyms: | CHEMBL196603 |
Type | Small organic molecule |
Emp. Form. | C30H40N4O3 |
Mol. Mass. | 504.6636 |
SMILES | CC(C)C[C@H]1N([C@@H](C(=O)NC(C)C)c2ccc(cc2)N(C)C)C(=O)[C@H](NC1=O)C1Cc2ccccc2C1 |
Structure |
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