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TargetD(2) dopamine receptor
LigandBDBM50050467
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1335160
Ki 7.5±n/a nM
Citation Xiao JFree RBBarnaeva EConroy JLDoyle TMiller BBryant-Genevier MTaylor MKHu XDulcey AESouthall NFerrer MTitus SZheng WSibley DRMarugan JJ Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists. J Med Chem 57:3450-63 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
D(2) dopamine receptor
Name:Dopamine receptor D2L/neurotensin receptor NTS1
Synonyms:DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like
Type:Cell-surface receptors
Mol. Mass.:50647.10
Organism:Homo sapiens (Human)
Description:P14416
Residue:443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC
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  Blast E-value cutoff:
BDBM50050467
n/a
NameBDBM50050467
Synonyms:1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperidin-4-ol | 3-[4-(4-chlorophenyl)-4-hydroxypiperidinyl]methylindole | 4-(4-Chloro-phenyl)-1-(1H-indol-3-ylmethyl)-piperidin-4-ol | CHEMBL445102 | L-741626 | L741,626
TypeSmall organic molecule
Emp. Form.C20H21ClN2O
Mol. Mass.340.847
SMILESOC1(CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(Cl)cc1
Structure
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