Reaction Details |
| Report a problem with these data |
Target | Endoplasmin |
---|
Ligand | BDBM50003868 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1336950 (CHEMBL3242258) |
---|
Ki | >10000±n/a nM |
---|
Citation | Ernst, JT; Neubert, T; Liu, M; Sperry, S; Zuccola, H; Turnbull, A; Fleck, B; Kargo, W; Woody, L; Chiang, P; Tran, D; Chen, W; Snyder, P; Alcacio, T; Nezami, A; Reynolds, J; Alvi, K; Goulet, L; Stamos, D Identification of novel HSP90a/ß isoform selective inhibitors using structure-based drug design. demonstration of potential utility in treating CNS disorders such as Huntington's disease. J Med Chem57:3382-400 (2014) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Endoplasmin |
---|
Name: | Endoplasmin |
Synonyms: | 94 kDa glucose-regulated protein | ENPL_HUMAN | GRP-94 | GRP94 | Glucose regulated protein 94kDa (Grp94) | HSP90B1 | Heat shock protein 90 kDa beta member 1 | TRA1 | Tumor rejection antigen 1 | gp96 homolog |
Type: | Protein |
Mol. Mass.: | 92417.36 |
Organism: | Homo sapiens (Human) |
Description: | P14625 |
Residue: | 803 |
Sequence: | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDG
LNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISL
TDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE
AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNT
LGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAK
EEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYK
SFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITD
DFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKY
NDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYF
MAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDE
SEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMER
IMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFET
ATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDE
EMDVGTDEEEETAKESTAEKDEL
|
|
|
BDBM50003868 |
---|
n/a |
---|
Name | BDBM50003868 |
Synonyms: | CHEMBL3235353 |
Type | Small organic molecule |
Emp. Form. | C25H30N2O2 |
Mol. Mass. | 390.5179 |
SMILES | Cc1cn(c2CC(C)(C)CC(=O)c12)-c1cc2CCNC(=O)c2c(c1)C1CCCC1 |
Structure |
|