| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 11 |
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| Ligand | BDBM50004757 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1337849 (CHEMBL3240677) |
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| IC50 | 900±n/a nM |
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| Citation |  Li, X; Inks, ES; Li, X; Hou, J; Chou, CJ; Zhang, J; Jiang, Y; Zhang, Y; Xu, W Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity. J Med Chem57:3324-41 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 11 |
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| Name: | Histone deacetylase 11 |
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| Synonyms: | HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11 |
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| Type: | Chromatin regulator; hydrolase; repressor |
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| Mol. Mass.: | 39187.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96DB2 |
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| Residue: | 347 |
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| Sequence: | MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
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| BDBM50004757 |
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| n/a |
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| Name | BDBM50004757 |
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| Synonyms: | CHEMBL3233698 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H24ClN3O4 |
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| Mol. Mass. | 489.95 |
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| SMILES | ONC(=O)\C=C\c1ccc(OC[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)cc2)cc1 |r| |
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| Structure | 
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