| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine receptor H4 |
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| Ligand | BDBM50006789 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1336245 (CHEMBL3241493) |
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| Ki | 306±n/a nM |
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| Citation |  Savall, BM; Chavez, F; Tays, K; Dunford, PJ; Cowden, JM; Hack, MD; Wolin, RL; Thurmond, RL; Edwards, JP Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H4 receptor antagonists. J Med Chem57:2429-39 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine receptor H4 |
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| Name: | Histamine receptor H4 |
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| Synonyms: | HISTAMINE H4 | HRH4 | Histamine H4 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44536.99 |
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| Organism: | GUINEA PIG |
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| Description: | HISTAMINE H4 HRH4 GUINEA PIG::Q91ZY3 |
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| Residue: | 389 |
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| Sequence: | MLANNSTIALTSIKISLTFLMSLLAIAIMLGNVVVILAFIVDRNLRHRSNYFFLNLAIAD
FFVGAIAIPLYIPSSLTYWTSGKQACVFWLITDYLLCTASVYNIVLISYDRYQSVSNAVW
YRAQHSGTWKIATQMVAVWIFSFMTNGPMILISDSWQNSTTECEPGFLKKWYFALPTSLL
EFLIPILLVAYFSAHIYWSLWKREKLSRCLSHPVLPSDSSSSDHGHSCRQDPDSRATLPA
RKETTASLGSDKSRRKSSLLFSIRAYKNSNVIASKMGFLSHSDSLALQQREHIELFRARK
LAKSLAILLAAFAICWAPYSLTTVIYSFFPERNLTKSTWYHTAFWLQWFNSFVNPFLYPL
CHKRFQKAFLKILPVRRQSTPPHNRSIST
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| BDBM50006789 |
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| n/a |
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| Name | BDBM50006789 |
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| Synonyms: | CHEMBL3236549 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H19N5 |
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| Mol. Mass. | 221.3021 |
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| SMILES | CC(C)c1cc(nc(N)n1)N1CC[C@@H](N)C1 |r| |
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| Structure | 
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