Reaction Details |
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Target | Proteasome subunit beta type-7 |
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Ligand | BDBM50069989 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1338348 (CHEMBL3240084) |
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IC50 | 120±n/a nM |
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Citation | Kawamura, S; Unno, Y; Asai, A; Arisawa, M; Shuto, S Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates. J Med Chem57:2726-35 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Proteasome subunit beta type-7 |
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Name: | Proteasome subunit beta type-7 |
Synonyms: | Macropain chain Z | Multicatalytic endopeptidase complex chain Z | PSB7_HUMAN | PSMB7 | Proteasome subunit Z | Z |
Type: | PROTEIN |
Mol. Mass.: | 29968.13 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_106197 |
Residue: | 277 |
Sequence: | MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGAD
TRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVV
TANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAV
FEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGT
RLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
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BDBM50069989 |
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n/a |
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Name | BDBM50069989 |
Synonyms: | (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid | (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-6-carboxamido)propanamido)butylboronic acid | BORTEZOMIB | CHEMBL325041 | Dipeptidyl boronic acid derivative | LDP-341 | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE | PS-341 | Peptidyl boronic acid derivative | US11542283, Compound Velcade | Velcade | cid_387447 |
Type | Small organic molecule |
Emp. Form. | C19H25BN4O4 |
Mol. Mass. | 384.237 |
SMILES | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O |r| |
Structure |
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