| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-7 |
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| Ligand | BDBM50007201 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1338347 (CHEMBL3240083) |
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| IC50 | 7.1±n/a nM |
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| Citation |  Kawamura, S; Unno, Y; Asai, A; Arisawa, M; Shuto, S Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates. J Med Chem57:2726-35 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-7 |
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| Name: | Proteasome subunit beta type-7 |
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| Synonyms: | Macropain chain Z | Multicatalytic endopeptidase complex chain Z | PSB7_HUMAN | PSMB7 | Proteasome subunit Z | Z |
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| Type: | PROTEIN |
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| Mol. Mass.: | 29968.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_106197 |
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| Residue: | 277 |
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| Sequence: | MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGAD
TRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVV
TANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAV
FEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGT
RLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
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| BDBM50007201 |
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| n/a |
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| Name | BDBM50007201 |
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| Synonyms: | CHEMBL3237870 |
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| Type | Small organic molecule |
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| Emp. Form. | C43H58BN5O7 |
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| Mol. Mass. | 767.761 |
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| SMILES | [H][C@@]12C[C@@]([H])(C1(C)C)[C@]1(C)OB(O[C@]1([H])C2)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)NCCC(COCc1ccccc1)COCc1ccccc1)NC(=O)c1cnccn1 |r| |
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| Structure | 
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