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TargetCasein kinase I isoform delta
LigandBDBM50008409
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1334961
IC50 9710±n/a nM
Citation Salado IGRedondo MBello MLPerez CLiachko NFKraemer BCMiguel LLecourtois MGil CMartinez APerez DI Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis. J Med Chem 57:2755-72 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Casein kinase I isoform delta
Name:Casein kinase I delta/epsilon
Synonyms:CKI-delta | CKId | CSNK1D | Casein kinase 1 delta (CK1δ) | Casein kinase I delta | Casein kinase I isoform delta (CK1D) | casein kinases 1 delta (CK1 delta)
Type:Enzyme
Mol. Mass.:47356.76
Organism:Homo sapiens (Human)
Description:P48730
Residue:415
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQ
GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRA
ADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPV
SGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
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  Blast E-value cutoff:
BDBM50008409
n/a
NameBDBM50008409
Synonyms:CHEMBL3235543
TypeSmall organic molecule
Emp. Form.C16H13ClN2O2S
Mol. Mass.332.805
SMILESCOc1ccc2nc(NC(=O)Cc3ccccc3Cl)sc2c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: