| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen phosphorylase, muscle form |
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| Ligand | BDBM50295847 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1338433 (CHEMBL3240699) |
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| Ki | 145000±n/a nM |
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| Citation |  Kun, S; Bokor, É; Varga, G; Szocs, B; Páhi, A; Czifrák, K; Tóth, M; Juhász, L; Docsa, T; Gergely, P; Somsák, L New synthesis of 3-(ß-D-glucopyranosyl)-5-substituted-1,2,4-triazoles, nanomolar inhibitors of glycogen phosphorylase. Eur J Med Chem76:567-79 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen phosphorylase, muscle form |
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| Name: | Glycogen phosphorylase, muscle form |
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| Synonyms: | Glycogen Phosphorylase (PYGM) | Glycogen phosphorylase a (RMGPa) | Glycogen phosphorylase, muscle form | Myophosphorylase | PYGM | PYGM_RABIT |
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| Type: | Enzyme |
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| Mol. Mass.: | 97296.32 |
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| Organism: | Oryctolagus cuniculus (rabbit) |
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| Description: | Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A. |
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| Residue: | 843 |
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| Sequence: | MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTV
RDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDM
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEA
DDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVN
TMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERL
DWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFP
GDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKF
QNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQ
ENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVV
PRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPA
ADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVD
RLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEE
YVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDE
KIP
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| BDBM50295847 |
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| n/a |
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| Name | BDBM50295847 |
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| Synonyms: | (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(5-methyl-1,3,4-oxadiazol-2-yl)tetrahydro-2H-pyran-3,4,5-triol | 2-(BETA-D-GLUCOPYRANOSYL)-5-METHYL-1,3,4-OXADIAZOLE | CHEMBL540929 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H14N2O6 |
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| Mol. Mass. | 246.2173 |
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| SMILES | Cc1nnc(o1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r| |
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| Structure | 
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