| Reaction Details |
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 | Report a problem with these data |
| Target | E3 SUMO-protein ligase CBX4 |
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| Ligand | BDBM50009555 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1336414 (CHEMBL3242418) |
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| Kd | 290±n/a nM |
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| Citation |  Simhadri, C; Daze, KD; Douglas, SF; Quon, TT; Dev, A; Gignac, MC; Peng, F; Heller, M; Boulanger, MJ; Wulff, JE; Hof, F Chromodomain antagonists that target the polycomb-group methyllysine reader protein chromobox homolog 7 (CBX7). J Med Chem57:2874-83 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| E3 SUMO-protein ligase CBX4 |
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| Name: | E3 SUMO-protein ligase CBX4 |
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| Synonyms: | 6.3.2.- | CBX4 | CBX4_HUMAN | Chromobox protein homolog 4 | Pc2 | Polycomb 2 homolog | hPc2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61401.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108273 |
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| Residue: | 560 |
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| Sequence: | MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQNR
ERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSSTDNRAKLDLGAQGKGQGHQY
ELNSKKHHQYQPHSKERAGKPPPPGKSGKYYYQLNSKKHHPYQPDPKMYDLQYQGGHKEA
PSPTCPDLGAKSHPPDKWAQGAGAKGYLGAVKPLAGAAGAPGKGSEKGPPNGMMPAPKEA
VTGNGIGGKMKIVKNKNKNGRIVIVMSKYMENGMQAVKIKSGEVAEGEARSPSHKKRAAD
ERHPPADRTFKKAAGAEEKKVEAPPKRREEEVSGVSDPQPQDAGSRKLSPTKEAFGEQPL
QLTTKPDLLAWDPARNTHPPSHHPHPHPHHHHHHHHHHHHAVGLNLSHVRKRCLSETHGE
REPCKKRLTARSISTPTCLGGSPAAERPADLPPAAALPQPEVILLDSDLDEPIDLRCVKT
RSEAGEPPSSLQVKPETPASAAVAVAAAAAPTTTAEKPPAEAQDEPAESLSEFKPFFGNI
IITDVTANCLTVTFKEYVTV
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| BDBM50009555 |
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| n/a |
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| Name | BDBM50009555 |
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| Synonyms: | CHEMBL3234443 |
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| Type | Small organic molecule |
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| Emp. Form. | C40H59N6O9 |
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| Mol. Mass. | 767.9307 |
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| SMILES | COC(=O)c1ccc(cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C1CCCC1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)NC(CO)CO |r| |
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| Structure | 
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