Reaction Details |
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Target | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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Ligand | BDBM22302 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1352296 (CHEMBL3269360) |
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IC50 | 21±n/a nM |
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Citation | Rai, G; Joshi, N; Jung, JE; Liu, Y; Schultz, L; Yasgar, A; Perry, S; Diaz, G; Zhang, Q; Kenyon, V; Jadhav, A; Simeonov, A; Lo, EH; van Leyen, K; Maloney, DJ; Holman, TR Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J Med Chem57:4035-48 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Polyunsaturated fatty acid lipoxygenase ALOX15 |
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Name: | Polyunsaturated fatty acid lipoxygenase ALOX15 |
Synonyms: | 15-Lipoxygenase | ALOX15 | Arachidonate 15-lipoxygenase | Erythroid cell-specific 15-lipoxygenase | LOX15_RABIT | Omega-6 lipoxygenase |
Type: | Enzyme |
Mol. Mass.: | 75309.71 |
Organism: | Oryctolagus cuniculus (rabbit) |
Description: | 15-LO enzyme was purified from phenylhydrazine treated rabbits. |
Residue: | 663 |
Sequence: | MGVYRVCVSTGASIYAGSKNKVELWLVGQHGEVELGSCLRPTRNKEEEFKVNVSKYLGSL
LFVRLRKKHFLKEDAWFCNWISVQALGAAEDKYWFPCYRWVVGDGVQSLPVGTGCTTVGD
PQGLFQKHREQELEERRKLYQWGSWKEGLILNVAGSKLTDLPVDERFLEDKKIDFEASLA
WGLAELALKNSLNILAPWKTLDDFNRIFWCGRSKLARRVRDSWQEDSLFGYQFLNGANPM
LLRRSVQLPARLVFPPGMEELQAQLEKELKAGTLFEADFALLDNIKANVILYCQQYLAAP
LVMLKLQPDGKLMPMVIQLHLPKIGSSPPPLFLPTDPPMVWLLAKCWVRSSDFQVHELNS
HLLRGHLMAEVFTVATMRCLPSIHPVFKLIVPHLRYTLEINVRARNGLVSDFGIFDQIMS
TGGGGHVQLLQQAGAFLTYRSFCPPDDLADRGLLGVESSFYAQDALRLWEIISRYVQGIM
GLYYKTDEAVRDDLELQSWCREITEIGLQGAQKQGFPTSLQSVAQACHFVTMCIFTCTGQ
HSSIHLGQLDWFTWVPNAPCTMRLPPPTTKDATLETVMATLPNLHQSSLQMSIVWQLGRD
QPIMVPLGQHQEEYFSGPEPRAVLEKFREELAIMDKEIEVRNEKLDIPYEYLRPSIVENS
VAI
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BDBM22302 |
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n/a |
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Name | BDBM22302 |
Synonyms: | N-{2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}-4-pentylbenzene-1-sulfonamide | tryptamine sulfonamide, 37l |
Type | Small organic molecule |
Emp. Form. | C29H30N2O3S |
Mol. Mass. | 486.625 |
SMILES | CCCCCc1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1 |
Structure |
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