Reaction Details |
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Target | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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Ligand | BDBM50011741 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1352297 (CHEMBL3269361) |
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IC50 | >40000±n/a nM |
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Citation | Rai, G; Joshi, N; Jung, JE; Liu, Y; Schultz, L; Yasgar, A; Perry, S; Diaz, G; Zhang, Q; Kenyon, V; Jadhav, A; Simeonov, A; Lo, EH; van Leyen, K; Maloney, DJ; Holman, TR Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J Med Chem57:4035-48 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Polyunsaturated fatty acid lipoxygenase ALOX15 |
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Name: | Polyunsaturated fatty acid lipoxygenase ALOX15 |
Synonyms: | 15-Lipoxygenase-1 (15-LOX-1) | ALOX15 | Arachidonate 15-lipoxygenase | Arachidonate 15-lipoxygenase-1 | LOG15 | LOX15_HUMAN | Reticulocyte 15-lipoxygenase-1 | Sphingosine 1-phosphate receptor 1 (S1P1) |
Type: | Protein |
Mol. Mass.: | 74804.05 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 662 |
Sequence: | MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL
LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP
QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK
GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV
LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL
VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH
LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST
GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS
LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH
ASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQ
PVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSV
AI
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BDBM50011741 |
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n/a |
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Name | BDBM50011741 |
Synonyms: | CHEMBL3262914 |
Type | Small organic molecule |
Emp. Form. | C13H10N4O |
Mol. Mass. | 238.2447 |
SMILES | CNc1oc(nc1C#N)-c1ccc2cc[nH]c2c1 |
Structure |
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