Reaction Details |
| Report a problem with these data |
Target | Prostaglandin E2 receptor EP4 subtype |
---|
Ligand | BDBM50012538 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1351394 (CHEMBL3266970) |
---|
Ki | 115±n/a nM |
---|
Citation | Sutton, J; Clark, DE; Higgs, C; de Groot, MJ; Harris, NV; Taylor, A; Lockey, PM; Maubach, K; Woodrooffe, A; Davis, RJ; Coleman, RA; Clark, KL From virtual to clinical: The discovery of PGN-1531, a novel antagonist of the prostanoid EP4 receptor. Bioorg Med Chem Lett24:2212-21 (2014) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Prostaglandin E2 receptor EP4 subtype |
---|
Name: | Prostaglandin E2 receptor EP4 subtype |
Synonyms: | PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor |
Type: | Enzyme |
Mol. Mass.: | 53134.53 |
Organism: | Homo sapiens (Human) |
Description: | P35408 |
Residue: | 488 |
Sequence: | MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG
LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA
INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA
HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG
HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQP
SLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSG
QHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPG
MGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSET
LNLSEKCI
|
|
|
BDBM50012538 |
---|
n/a |
---|
Name | BDBM50012538 |
Synonyms: | CHEMBL3260762 |
Type | Small organic molecule |
Emp. Form. | C22H24N2O6S |
Mol. Mass. | 444.501 |
SMILES | COc1ccc(cc1)-c1ccc(OCc2cc(oc2C)C(=O)NS(=O)(=O)N(C)C)cc1 |
Structure |
|