Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | E3 ubiquitin-protein ligase Mdm2 | ||
Ligand | BDBM50012589 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1351457 (CHEMBL3267322) | ||
IC50 | 3.0±n/a nM | ||
Citation | Vaupel, A; Bold, G; De Pover, A; Stachyra-Valat, T; Hergovich-Lisztwan, J; Kallen, J; Masuya, K; Furet, P Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction. Bioorg Med Chem Lett24:2110-4 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
E3 ubiquitin-protein ligase Mdm2 | |||
Name: | E3 ubiquitin-protein ligase Mdm2 | ||
Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein | ||
Type: | Oncoprotein | ||
Mol. Mass.: | 55196.54 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q00987 | ||
Residue: | 491 | ||
Sequence: |
| ||
BDBM50012589 | |||
n/a | |||
Name | BDBM50012589 | ||
Synonyms: | CHEMBL3260816 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H18Cl2F2N6 | ||
Mol. Mass. | 475.321 | ||
SMILES | Fc1ccc(cc1Cl)-c1c(nc(C2CCCCC2)n1-c1cccc(Cl)c1F)-c1nnn[nH]1 |(48.97,-18.08,;50.51,-18.09,;51.28,-19.43,;52.82,-19.43,;53.59,-18.11,;52.83,-16.77,;51.29,-16.76,;50.53,-15.42,;55.13,-18.11,;55.65,-16.67,;57.19,-16.72,;57.61,-18.2,;59.06,-18.73,;59.32,-20.25,;60.77,-20.78,;61.95,-19.79,;61.68,-18.27,;60.23,-17.74,;56.34,-19.06,;56.28,-20.59,;54.92,-21.31,;54.86,-22.85,;56.17,-23.67,;57.53,-22.94,;58.84,-23.76,;57.58,-21.41,;58.94,-20.68,;54.78,-15.39,;53.24,-15.34,;52.82,-13.86,;54.09,-13,;55.31,-13.94,)| | ||
Structure |