Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | E3 ubiquitin-protein ligase Mdm2 | ||
Ligand | BDBM50012590 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1351457 (CHEMBL3267322) | ||
IC50 | 4.0±n/a nM | ||
Citation | Vaupel, A; Bold, G; De Pover, A; Stachyra-Valat, T; Hergovich-Lisztwan, J; Kallen, J; Masuya, K; Furet, P Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction. Bioorg Med Chem Lett24:2110-4 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
E3 ubiquitin-protein ligase Mdm2 | |||
Name: | E3 ubiquitin-protein ligase Mdm2 | ||
Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein | ||
Type: | Oncoprotein | ||
Mol. Mass.: | 55196.54 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q00987 | ||
Residue: | 491 | ||
Sequence: |
| ||
BDBM50012590 | |||
n/a | |||
Name | BDBM50012590 | ||
Synonyms: | CHEMBL3260814 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H18Cl2F2N2O2 | ||
Mol. Mass. | 451.293 | ||
SMILES | OC(=O)c1nc(C2CCCCC2)n(c1-c1ccc(F)c(Cl)c1)-c1cccc(Cl)c1F |(23.17,-13.47,;22.5,-14.86,;20.96,-14.97,;23.36,-16.14,;24.91,-16.19,;25.33,-17.67,;26.77,-18.2,;27.04,-19.72,;28.48,-20.25,;29.67,-19.26,;29.39,-17.74,;27.95,-17.21,;24.05,-18.53,;22.84,-17.58,;21.3,-17.58,;20.53,-18.9,;18.99,-18.9,;18.22,-17.56,;16.68,-17.55,;19,-16.23,;18.24,-14.89,;20.54,-16.24,;24,-20.07,;22.63,-20.79,;22.58,-22.32,;23.88,-23.14,;25.25,-22.41,;26.56,-23.23,;25.3,-20.88,;26.66,-20.15,)| | ||
Structure |