Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | E3 ubiquitin-protein ligase Mdm2 | ||
Ligand | BDBM50012592 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1351457 (CHEMBL3267322) | ||
IC50 | 6.0±n/a nM | ||
Citation | Vaupel, A; Bold, G; De Pover, A; Stachyra-Valat, T; Hergovich-Lisztwan, J; Kallen, J; Masuya, K; Furet, P Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction. Bioorg Med Chem Lett24:2110-4 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
E3 ubiquitin-protein ligase Mdm2 | |||
Name: | E3 ubiquitin-protein ligase Mdm2 | ||
Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein | ||
Type: | Oncoprotein | ||
Mol. Mass.: | 55196.54 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q00987 | ||
Residue: | 491 | ||
Sequence: |
| ||
BDBM50012592 | |||
n/a | |||
Name | BDBM50012592 | ||
Synonyms: | CHEMBL3260818 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H19Cl2F2N5O | ||
Mol. Mass. | 490.333 | ||
SMILES | Nc1nnc(o1)-c1nc(C2CCCCC2)n(c1-c1ccc(F)c(Cl)c1)-c1cccc(Cl)c1F |(19.48,-25.13,;19.43,-26.67,;18.15,-27.53,;18.58,-29.01,;20.12,-29.06,;20.64,-27.62,;20.99,-30.34,;22.53,-30.39,;22.95,-31.88,;24.4,-32.4,;24.66,-33.92,;26.1,-34.45,;27.29,-33.46,;27.02,-31.94,;25.57,-31.42,;21.67,-32.74,;20.46,-31.79,;18.93,-31.78,;18.16,-33.11,;16.62,-33.1,;15.85,-31.76,;14.31,-31.75,;16.63,-30.43,;15.86,-29.09,;18.17,-30.44,;21.62,-34.27,;20.26,-34.99,;20.2,-36.52,;21.51,-37.34,;22.87,-36.62,;24.18,-37.43,;22.92,-35.08,;24.28,-34.35,)| | ||
Structure |