Reaction Details |
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Target | Tyrosine-protein kinase ITK/TSK |
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Ligand | BDBM50015263 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1349759 (CHEMBL3267591) |
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Ki | 0.560000±n/a nM |
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Citation | Pastor, RM; Burch, JD; Magnuson, S; Ortwine, DF; Chen, Y; De La Torre, K; Ding, X; Eigenbrot, C; Johnson, A; Liimatta, M; Liu, Y; Shia, S; Wang, X; Wu, LC; Pei, Z Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors. Bioorg Med Chem Lett24:2448-52 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase ITK/TSK |
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Name: | Tyrosine-protein kinase ITK/TSK |
Synonyms: | EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk |
Type: | Protein |
Mol. Mass.: | 71839.20 |
Organism: | Homo sapiens (Human) |
Description: | Q08881 |
Residue: | 620 |
Sequence: | MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
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BDBM50015263 |
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n/a |
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Name | BDBM50015263 |
Synonyms: | CHEMBL3263050 |
Type | Small organic molecule |
Emp. Form. | C22H19N7O2 |
Mol. Mass. | 413.432 |
SMILES | OC[C@@H](c1ccccc1)n1cc(NC(=O)c2n[nH]c3cc(ccc23)-c2cn[nH]c2)cn1 |r| |
Structure |
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