| Reaction Details |
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 | Report a problem with these data |
| Target | Legumain |
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| Ligand | BDBM50015362 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1347909 (CHEMBL3267446) |
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| IC50 | 0.900000±n/a nM |
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| Citation |  Higgins, C; Bouazzaoui, S; Gaddale, K; D'Costa, Z; Templeman, A; O'Rourke, M; Young, A; Scott, C; Harrison, T; Mullan, P; Williams, R P3 SAR exploration of biphenyl carbamate based Legumain inhibitors. Bioorg Med Chem Lett24:2521-4 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Legumain |
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| Name: | Legumain |
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| Synonyms: | 3.4.22.34 | Asparaginyl endopeptidase | LGMN | LGMN_HUMAN | PRSC1 | Protease, cysteine 1 |
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| Type: | n/a |
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| Mol. Mass.: | 49411.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 433 |
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| Sequence: | MVWKVAVFLSVALGIGAVPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNG
IPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGD
AEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYR
KMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMED
SDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVT
HLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASE
AEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHR
IKLSMDHVCLGHY
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| BDBM50015362 |
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| n/a |
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| Name | BDBM50015362 |
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| Synonyms: | CHEMBL3264590 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28N4O5 |
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| Mol. Mass. | 464.5136 |
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| SMILES | CCOc1cccc(c1)-c1ccc(COC(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(N)=O)C#N)cc1 |r| |
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| Structure | 
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