Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM50016463

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1347647 (CHEMBL3270686)

457±n/a nM

Citation

Chen, J; Levant, B; Jiang, C; Keck, TM; Newman, AH; Wang, S Tranylcypromine substituted cis-hydroxycyclobutylnaphthamides as potent and selective dopamine D3 receptor antagonists. J Med Chem57:4962-8 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3

Type:

Protein

Mol. Mass.:

49540.58

Organism:

Rattus norvegicus (Rat)

Description:

P19020

Residue:

446

Sequence:

MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSI
CSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQ
QSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLK
RYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGP
LQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYV
NSALNPVIYTTFNVEFRKAFLKILSC

BDBM50016463

n/a

Name

BDBM50016463

Synonyms:

CHEMBL3265066

Type

Small organic molecule

Emp. Form.

C29H33ClN2O2

Mol. Mass.

477.038

SMILES

CCCN(CC[C@@]1(O)C[C@@H](C1)NC(=O)c1ccc2ccccc2c1)[C@H]1C[C@@H]1c1ccc(Cl)cc1 |r,wU:26.30,9.11,6.6,wD:24.26,(11.39,-45.37,;11.38,-43.83,;10.04,-43.06,;10.03,-41.52,;11.36,-40.75,;12.7,-41.51,;14.03,-40.73,;14.42,-42.21,;15.51,-41.13,;15.9,-39.64,;14.41,-39.25,;17.23,-38.86,;18.57,-39.63,;18.58,-41.17,;19.9,-38.85,;19.88,-37.32,;21.21,-36.54,;22.55,-37.3,;23.87,-36.53,;25.21,-37.28,;25.22,-38.83,;23.89,-39.6,;22.56,-38.84,;21.23,-39.62,;8.7,-40.76,;7.92,-39.43,;7.16,-40.77,;5.83,-41.54,;4.49,-40.78,;3.16,-41.55,;3.16,-43.1,;1.83,-43.86,;4.5,-43.87,;5.83,-43.09,)|

Structure