| Reaction Details |
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 | Report a problem with these data |
| Target | Pyruvate kinase PKLR |
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| Ligand | BDBM50016876 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1359662 (CHEMBL3282777) |
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| Kd | 36000000±n/a nM |
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| Citation |  Hampton, A; Kappler, F; Maeda, M; Patel, AD Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 2. Isozyme-specific inactivation of a mammalian enzyme and its significance in the possible design of fetal isozyme targeted antineoplastic agents. J Med Chem21:1137-40 (1979) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Pyruvate kinase PKLR |
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| Name: | Pyruvate kinase PKLR |
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| Synonyms: | KPYR_RAT | Pklr | Pyruvate kinase isozymes R/L |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62202.26 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1359662 |
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| Residue: | 574 |
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| Sequence: | MSVQENTLPQQLWPWIFRSQKDLAKSALSGAPGGPAGYLRRASVAQLTQELGTAFFQQQQ
LPAAMADTFLEHLCLLDIDSQPVAARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFS
HGSHEYHAESIANIREATESFATSPLSYRPVAIALDTKGPEIRTGVLQGGPESEVEIVKG
SQVLVTVDPKFQTRGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEV
EHGGILGSRKGVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDA
LGPEGQNIKIISKIENHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRC
NLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLSGETAKGSFPVEAVMM
QHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRS
AQLLSQYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPPEAIWADDVDRRVQFGIESG
KLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSVS
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| BDBM50016876 |
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| n/a |
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| Name | BDBM50016876 |
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| Synonyms: | CHEMBL3278432 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H33IN6O11P2 |
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| Mol. Mass. | 722.3616 |
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| SMILES | O[C@@H]1[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c(NCCCCCCCCNC(=O)CI)ncnc12 |r| |
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| Structure | 
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