| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 3 |
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| Ligand | BDBM50017601 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1364013 (CHEMBL3295852) |
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| IC50 | 696±n/a nM |
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| Citation |  Wenthur, CJ; Morrison, RD; Daniels, JS; Conn, PJ; Lindsley, CW Synthesis and SAR of substituted pyrazolo[1,5-a]quinazolines as dual mGlu(2)/mGlu(3) NAMs. Bioorg Med Chem Lett24:2693-8 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 3 |
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| Name: | Metabotropic glutamate receptor 3 |
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| Synonyms: | GRM3_RAT | Gprc1c | Grm3 | Mglur3 | glutamate receptor, metabotropic 3 precursor |
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| Type: | Protein |
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| Mol. Mass.: | 98971.84 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P31422 |
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| Residue: | 879 |
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| Sequence: | MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRI
NEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV
DEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSD
KSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNIC
IATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVAS
DGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ
CSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD
AMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSY
LKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL
VDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIK
HNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALL
TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLP
EKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCI
IWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLH
LNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL
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| BDBM50017601 |
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| n/a |
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| Name | BDBM50017601 |
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| Synonyms: | CHEMBL3288646 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H20N4O4S |
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| Mol. Mass. | 460.505 |
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| SMILES | COc1cccc(c1)-c1cc2n(C)c(=O)c3ccc(cc3n2n1)-c1cccc(c1)S(N)(=O)=O |
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| Structure | 
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