Compile Data Set for Download or QSAR

Found 91 hits with Last Name = 'wenthur' and Initial = 'cj'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017610 (CHEMBL3288662) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cccnc1)-c1ccc(F)cc1 Show InChI InChI=1S/C22H15FN4O/c1-26-21-12-19(14-4-7-17(23)8-5-14)25-27(21)20-11-15(6-9-18(20)22(26)28)16-3-2-10-24-13-16/h2-13H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017663 (CHEMBL3288676) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cncnc1)-c1ccccc1 Show InChI InChI=1S/C21H15N5O/c1-25-20-10-18(14-5-3-2-4-6-14)24-26(20)19-9-15(7-8-17(19)21(25)27)16-11-22-13-23-12-16/h2-13H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017663 (CHEMBL3288676) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cncnc1)-c1ccccc1 Show InChI InChI=1S/C21H15N5O/c1-25-20-10-18(14-5-3-2-4-6-14)24-26(20)19-9-15(7-8-17(19)21(25)27)16-11-22-13-23-12-16/h2-13H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017598 (CHEMBL3288639) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cccnc1)-c1ccccc1 Show InChI InChI=1S/C22H16N4O/c1-25-21-13-19(15-6-3-2-4-7-15)24-26(21)20-12-16(9-10-18(20)22(25)27)17-8-5-11-23-14-17/h2-14H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	165	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50401091 (CHEMBL2204436 | CHEMBL2385894) Show SMILES Clc1ccc(CN[C@H]2CCN(C2)c2ncc(Br)cn2)c(Cl)c1 |r| Show InChI InChI=1S/C15H15BrCl2N4/c16-11-7-20-15(21-8-11)22-4-3-13(9-22)19-6-10-1-2-12(17)5-14(10)18/h1-2,5,7-8,13,19H,3-4,6,9H2/t13-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu3 expressed in AV-12 cells in presence of glutamate EC90 concentration by FLIPR assay				Bioorg Med Chem Lett 22: 3921-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.112 BindingDB Entry DOI: 10.7270/Q21N828X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50017663 (CHEMBL3288676) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cncnc1)-c1ccccc1 Show InChI InChI=1S/C21H15N5O/c1-25-20-10-18(14-5-3-2-4-6-14)24-26(20)19-9-15(7-8-17(19)21(25)27)16-11-22-13-23-12-16/h2-13H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	245	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu2 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50017663 (CHEMBL3288676) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cncnc1)-c1ccccc1 Show InChI InChI=1S/C21H15N5O/c1-25-20-10-18(14-5-3-2-4-6-14)24-26(20)19-9-15(7-8-17(19)21(25)27)16-11-22-13-23-12-16/h2-13H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	245	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu2 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017600 (CHEMBL3288644) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cccnc1)-c1cccc(F)c1 Show InChI InChI=1S/C22H15FN4O/c1-26-21-12-19(15-4-2-6-17(23)10-15)25-27(21)20-11-14(7-8-18(20)22(26)28)16-5-3-9-24-13-16/h2-13H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	247	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50332963 (4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...) Show SMILES Cc1cc(cc(C)n1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F |t:16| Show InChI InChI=1S/C24H20F3N3O/c1-13-7-21-22(11-19(13)24(25,26)27)30-23(31)12-20(29-21)17-6-4-5-16(10-17)18-8-14(2)28-15(3)9-18/h4-11H,12H2,1-3H3,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu3 receptor (unknown origin)				J Med Chem 56: 5208-12 (2013) Article DOI: 10.1021/jm400439t BindingDB Entry DOI: 10.7270/Q23F4R2J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50332963 (4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...) Show SMILES Cc1cc(cc(C)n1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F |t:16| Show InChI InChI=1S/C24H20F3N3O/c1-13-7-21-22(11-19(13)24(25,26)27)30-23(31)12-20(29-21)17-6-4-5-16(10-17)18-8-14(2)28-15(3)9-18/h4-11H,12H2,1-3H3,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu3 by cell-based assay				Bioorg Med Chem Lett 22: 3921-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.112 BindingDB Entry DOI: 10.7270/Q21N828X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017606 (CHEMBL3288656) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cccnc1)-c1cccc(Cl)c1 Show InChI InChI=1S/C22H15ClN4O/c1-26-21-12-19(15-4-2-6-17(23)10-15)25-27(21)20-11-14(7-8-18(20)22(26)28)16-5-3-9-24-13-16/h2-13H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	293	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50332963 (4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...) Show SMILES Cc1cc(cc(C)n1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F |t:16| Show InChI InChI=1S/C24H20F3N3O/c1-13-7-21-22(11-19(13)24(25,26)27)30-23(31)12-20(29-21)17-6-4-5-16(10-17)18-8-14(2)28-15(3)9-18/h4-11H,12H2,1-3H3,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	296	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu2 receptor (unknown origin)				J Med Chem 56: 5208-12 (2013) Article DOI: 10.1021/jm400439t BindingDB Entry DOI: 10.7270/Q23F4R2J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50332963 (4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...) Show SMILES Cc1cc(cc(C)n1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F |t:16| Show InChI InChI=1S/C24H20F3N3O/c1-13-7-21-22(11-19(13)24(25,26)27)30-23(31)12-20(29-21)17-6-4-5-16(10-17)18-8-14(2)28-15(3)9-18/h4-11H,12H2,1-3H3,(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	296	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu2 by cell-based assay				Bioorg Med Chem Lett 22: 3921-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.112 BindingDB Entry DOI: 10.7270/Q21N828X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50017610 (CHEMBL3288662) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cccnc1)-c1ccc(F)cc1 Show InChI InChI=1S/C22H15FN4O/c1-26-21-12-19(14-4-7-17(23)8-5-14)25-27(21)20-11-15(6-9-18(20)22(26)28)16-3-2-10-24-13-16/h2-13H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	427	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu2 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017661 (CHEMBL3288675) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1ccncc1)-c1ccccc1 Show InChI InChI=1S/C22H16N4O/c1-25-21-14-19(16-5-3-2-4-6-16)24-26(21)20-13-17(7-8-18(20)22(25)27)15-9-11-23-12-10-15/h2-14H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	509	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017605 (CHEMBL3288653) Show SMILES Cc1cccc(c1)-c1cc2n(C)c(=O)c3ccc(cc3n2n1)-c1cccnc1 Show InChI InChI=1S/C23H18N4O/c1-15-5-3-6-17(11-15)20-13-22-26(2)23(28)19-9-8-16(12-21(19)27(22)25-20)18-7-4-10-24-14-18/h3-14H,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50017606 (CHEMBL3288656) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cccnc1)-c1cccc(Cl)c1 Show InChI InChI=1S/C22H15ClN4O/c1-26-21-12-19(15-4-2-6-17(23)10-15)25-27(21)20-11-14(7-8-18(20)22(26)28)16-5-3-9-24-13-16/h2-13H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	564	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu2 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017654 (CHEMBL3288667) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cccnc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C22H15ClN4O/c1-26-21-12-19(14-4-7-17(23)8-5-14)25-27(21)20-11-15(6-9-18(20)22(26)28)16-3-2-10-24-13-16/h2-13H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	645	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50401086 (CHEMBL2204445) Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC[C@@H](CO)C1 |r| Show InChI InChI=1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu3 assessed as inhibition of glutamate-induced calcium mobilization in presence of Galpha15 by cell based assay				Bioorg Med Chem Lett 22: 3921-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.112 BindingDB Entry DOI: 10.7270/Q21N828X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017601 (CHEMBL3288646) Show SMILES COc1cccc(c1)-c1cc2n(C)c(=O)c3ccc(cc3n2n1)-c1cccc(c1)S(N)(=O)=O Show InChI InChI=1S/C24H20N4O4S/c1-27-23-14-21(17-6-3-7-18(11-17)32-2)26-28(23)22-13-16(9-10-20(22)24(27)29)15-5-4-8-19(12-15)33(25,30)31/h3-14H,1-2H3,(H2,25,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	696	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50017612 (CHEMBL3288664) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cccc(c1)S(N)(=O)=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C23H17ClN4O3S/c1-27-22-13-20(14-5-8-17(24)9-6-14)26-28(22)21-12-16(7-10-19(21)23(27)29)15-3-2-4-18(11-15)32(25,30)31/h2-13H,1H3,(H2,25,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	847	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu2 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50017598 (CHEMBL3288639) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cccnc1)-c1ccccc1 Show InChI InChI=1S/C22H16N4O/c1-25-21-13-19(15-6-3-2-4-7-15)24-26(21)20-12-16(9-10-18(20)22(25)27)17-8-5-11-23-14-17/h2-14H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	852	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu2 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017596 (CHEMBL3288636) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cccc(c1)S(N)(=O)=O)-c1ccccc1 Show InChI InChI=1S/C23H18N4O3S/c1-26-22-14-20(15-6-3-2-4-7-15)25-27(22)21-13-17(10-11-19(21)23(26)28)16-8-5-9-18(12-16)31(24,29)30/h2-14H,1H3,(H2,24,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	884	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50017654 (CHEMBL3288667) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cccnc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C22H15ClN4O/c1-26-21-12-19(14-4-7-17(23)8-5-14)25-27(21)20-11-15(6-9-18(20)22(26)28)16-3-2-10-24-13-16/h2-13H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.11E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu2 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017603 (CHEMBL3288649) Show SMILES COc1cccc(c1)-c1cc2n(C)c(=O)c3ccc(cc3n2n1)-c1cccnc1 Show InChI InChI=1S/C23H18N4O2/c1-26-22-13-20(16-5-3-7-18(11-16)29-2)25-27(22)21-12-15(8-9-19(21)23(26)28)17-6-4-10-24-14-17/h3-14H,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017612 (CHEMBL3288664) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cccc(c1)S(N)(=O)=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C23H17ClN4O3S/c1-27-22-13-20(14-5-8-17(24)9-6-14)26-28(22)21-12-16(7-10-19(21)23(27)29)15-3-2-4-18(11-15)32(25,30)31/h2-13H,1H3,(H2,25,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50017601 (CHEMBL3288646) Show SMILES COc1cccc(c1)-c1cc2n(C)c(=O)c3ccc(cc3n2n1)-c1cccc(c1)S(N)(=O)=O Show InChI InChI=1S/C24H20N4O4S/c1-27-23-14-21(17-6-3-7-18(11-17)32-2)26-28(23)22-13-16(9-10-20(22)24(27)29)15-5-4-8-19(12-15)33(25,30)31/h3-14H,1-2H3,(H2,25,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu2 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50401086 (CHEMBL2204445) Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC[C@@H](CO)C1 |r| Show InChI InChI=1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.48E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay				Bioorg Med Chem Lett 22: 3921-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.112 BindingDB Entry DOI: 10.7270/Q21N828X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50401086 (CHEMBL2204445) Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC[C@@H](CO)C1 |r| Show InChI InChI=1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay				Bioorg Med Chem Lett 22: 3921-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.112 BindingDB Entry DOI: 10.7270/Q21N828X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50017600 (CHEMBL3288644) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cccnc1)-c1cccc(F)c1 Show InChI InChI=1S/C22H15FN4O/c1-26-21-12-19(15-4-2-6-17(23)10-15)25-27(21)20-11-14(7-8-18(20)22(26)28)16-5-3-9-24-13-16/h2-13H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.56E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu2 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50017661 (CHEMBL3288675) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1ccncc1)-c1ccccc1 Show InChI InChI=1S/C22H16N4O/c1-25-21-14-19(16-5-3-2-4-6-16)24-26(21)20-13-17(7-8-18(20)22(25)27)15-9-11-23-12-10-15/h2-14H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.77E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu2 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50017605 (CHEMBL3288653) Show SMILES Cc1cccc(c1)-c1cc2n(C)c(=O)c3ccc(cc3n2n1)-c1cccnc1 Show InChI InChI=1S/C23H18N4O/c1-15-5-3-6-17(11-15)20-13-22-26(2)23(28)19-9-8-16(12-21(19)27(22)25-20)18-7-4-10-24-14-18/h3-14H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.79E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu2 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50017596 (CHEMBL3288636) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cccc(c1)S(N)(=O)=O)-c1ccccc1 Show InChI InChI=1S/C23H18N4O3S/c1-26-22-14-20(15-6-3-2-4-7-15)25-27(22)21-13-17(10-11-19(21)23(26)28)16-8-5-9-18(12-16)31(24,29)30/h2-14H,1H3,(H2,24,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.93E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu2 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017608 (CHEMBL3288660) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cccc(c1)S(N)(=O)=O)-c1ccc(F)cc1 Show InChI InChI=1S/C23H17FN4O3S/c1-27-22-13-20(14-5-8-17(24)9-6-14)26-28(22)21-12-16(7-10-19(21)23(27)29)15-3-2-4-18(11-15)32(25,30)31/h2-13H,1H3,(H2,25,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.99E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50401085 (CHEMBL2204446) Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC[C@H](CO)C1 |r| Show InChI InChI=1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay				Bioorg Med Chem Lett 22: 3921-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.112 BindingDB Entry DOI: 10.7270/Q21N828X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50401085 (CHEMBL2204446) Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC[C@H](CO)C1 |r| Show InChI InChI=1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay				Bioorg Med Chem Lett 22: 3921-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.112 BindingDB Entry DOI: 10.7270/Q21N828X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50401088 (CHEMBL2204439) Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCCC(O)C1 Show InChI InChI=1S/C21H21NO3/c1-25-20-12-8-17(9-13-20)5-4-16-6-10-18(11-7-16)21(24)22-14-2-3-19(23)15-22/h6-13,19,23H,2-3,14-15H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay				Bioorg Med Chem Lett 22: 3921-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.112 BindingDB Entry DOI: 10.7270/Q21N828X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50401088 (CHEMBL2204439) Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCCC(O)C1 Show InChI InChI=1S/C21H21NO3/c1-25-20-12-8-17(9-13-20)5-4-16-6-10-18(11-7-16)21(24)22-14-2-3-19(23)15-22/h6-13,19,23H,2-3,14-15H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay				Bioorg Med Chem Lett 22: 3921-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.112 BindingDB Entry DOI: 10.7270/Q21N828X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50017603 (CHEMBL3288649) Show SMILES COc1cccc(c1)-c1cc2n(C)c(=O)c3ccc(cc3n2n1)-c1cccnc1 Show InChI InChI=1S/C23H18N4O2/c1-26-22-13-20(16-5-3-7-18(11-16)29-2)25-27(22)21-12-15(8-9-19(21)23(26)28)17-6-4-10-24-14-17/h3-14H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu2 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017660 (CHEMBL3288674) Show SMILES OCCn1c2cc(nn2c2cc(ccc2c1=O)-c1cccnc1)-c1ccccc1 Show InChI InChI=1S/C23H18N4O2/c28-12-11-26-22-14-20(16-5-2-1-3-6-16)25-27(22)21-13-17(8-9-19(21)23(26)29)18-7-4-10-24-15-18/h1-10,13-15,28H,11-12H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50401085 (CHEMBL2204446) Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC[C@H](CO)C1 |r| Show InChI InChI=1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay				Bioorg Med Chem Lett 22: 3921-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.112 BindingDB Entry DOI: 10.7270/Q21N828X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50401090 (CHEMBL2204437) Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC(O)CC1 Show InChI InChI=1S/C21H21NO3/c1-25-20-10-6-17(7-11-20)3-2-16-4-8-18(9-5-16)21(24)22-14-12-19(23)13-15-22/h4-11,19,23H,12-15H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay				Bioorg Med Chem Lett 22: 3921-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.112 BindingDB Entry DOI: 10.7270/Q21N828X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50401090 (CHEMBL2204437) Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC(O)CC1 Show InChI InChI=1S/C21H21NO3/c1-25-20-10-6-17(7-11-20)3-2-16-4-8-18(9-5-16)21(24)22-14-12-19(23)13-15-22/h4-11,19,23H,12-15H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay				Bioorg Med Chem Lett 22: 3921-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.112 BindingDB Entry DOI: 10.7270/Q21N828X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50017608 (CHEMBL3288660) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1cccc(c1)S(N)(=O)=O)-c1ccc(F)cc1 Show InChI InChI=1S/C23H17FN4O3S/c1-27-22-13-20(14-5-8-17(24)9-6-14)26-28(22)21-12-16(7-10-19(21)23(27)29)15-3-2-4-18(11-15)32(25,30)31/h2-13H,1H3,(H2,25,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu2 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50401091 (CHEMBL2204436 | CHEMBL2385894) Show SMILES Clc1ccc(CN[C@H]2CCN(C2)c2ncc(Br)cn2)c(Cl)c1 |r| Show InChI InChI=1S/C15H15BrCl2N4/c16-11-7-20-15(21-8-11)22-4-3-13(9-22)19-6-10-1-2-12(17)5-14(10)18/h1-2,5,7-8,13,19H,3-4,6,9H2/t13-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu3 receptor assessed as Ca2+ flux by FLIPR assay				J Med Chem 56: 5208-12 (2013) Article DOI: 10.1021/jm400439t BindingDB Entry DOI: 10.7270/Q23F4R2J
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50401091 (CHEMBL2204436 | CHEMBL2385894) Show SMILES Clc1ccc(CN[C@H]2CCN(C2)c2ncc(Br)cn2)c(Cl)c1 |r| Show InChI InChI=1S/C15H15BrCl2N4/c16-11-7-20-15(21-8-11)22-4-3-13(9-22)19-6-10-1-2-12(17)5-14(10)18/h1-2,5,7-8,13,19H,3-4,6,9H2/t13-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay				Bioorg Med Chem Lett 22: 3921-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.112 BindingDB Entry DOI: 10.7270/Q21N828X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017665 (CHEMBL3288680) Show SMILES Cn1c2cc(nn2c2cc(ccc2c1=O)-c1ccc2ccncc2c1)-c1ccccc1 Show InChI InChI=1S/C26H18N4O/c1-29-25-15-23(18-5-3-2-4-6-18)28-30(25)24-14-20(9-10-22(24)26(29)31)19-8-7-17-11-12-27-16-21(17)13-19/h2-16H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50017660 (CHEMBL3288674) Show SMILES OCCn1c2cc(nn2c2cc(ccc2c1=O)-c1cccnc1)-c1ccccc1 Show InChI InChI=1S/C23H18N4O2/c28-12-11-26-22-14-20(16-5-2-1-3-6-16)25-27(22)21-13-17(8-9-19(21)23(26)29)18-7-4-10-24-15-18/h1-10,13-15,28H,11-12H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.65E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of rat mGlu2 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...				Bioorg Med Chem Lett 24: 2693-8 (2014) Article DOI: 10.1016/j.bmcl.2014.04.051 BindingDB Entry DOI: 10.7270/Q228094H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50401089 (CHEMBL2204438) Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC(C)(O)CC1 Show InChI InChI=1S/C22H23NO3/c1-22(25)13-15-23(16-14-22)21(24)19-9-5-17(6-10-19)3-4-18-7-11-20(26-2)12-8-18/h5-12,25H,13-16H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay				Bioorg Med Chem Lett 22: 3921-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.112 BindingDB Entry DOI: 10.7270/Q21N828X
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50401089 (CHEMBL2204438) Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC(C)(O)CC1 Show InChI InChI=1S/C22H23NO3/c1-22(25)13-15-23(16-14-22)21(24)19-9-5-17(6-10-19)3-4-18-7-11-20(26-2)12-8-18/h5-12,25H,13-16H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.01E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assay				Bioorg Med Chem Lett 22: 3921-5 (2012) Article DOI: 10.1016/j.bmcl.2012.04.112 BindingDB Entry DOI: 10.7270/Q21N828X
					More data for this Ligand-Target Pair

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