| Reaction Details |
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 | Report a problem with these data |
| Target | Ras guanyl-releasing protein 3 |
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| Ligand | BDBM50244449 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1364407 (CHEMBL3294519) |
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| Ki | 0.330000±n/a nM |
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| Citation |  Garcia, LC; Donadío, LG; Mann, E; Kolusheva, S; Kedei, N; Lewin, NE; Hill, CS; Kelsey, JS; Yang, J; Esch, TE; Santos, M; Peach, ML; Kelley, JA; Blumberg, PM; Jelinek, R; Marquez, VE; Comin, MJ Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP. Bioorg Med Chem22:3123-40 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ras guanyl-releasing protein 3 |
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| Name: | Ras guanyl-releasing protein 3 |
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| Synonyms: | GRP3 | GRP3_HUMAN | KIAA0846 | RAS guanyl releasing protein 3 | RASGRP3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78335.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1364407 |
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| Residue: | 690 |
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| Sequence: | MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR
NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI
SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV
IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT
LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP
ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL
TLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKH
IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR
AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL
VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK
ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV
HAGVDVVDRGTEFELDQDEGEETRQDGEDG
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| BDBM50244449 |
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| n/a |
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| Name | BDBM50244449 |
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| Synonyms: | (E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)methylene)-5-oxo-tetrahydrofuran-2-yl)methyl 2-propylpentanoate | CHEMBL519741 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H31NO5 |
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| Mol. Mass. | 413.5066 |
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| SMILES | CCCC(CCC)C(=O)OCC1(CO)C\C(=C/c2cn(C)c3ccccc23)C(=O)O1 |
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| Structure | 
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