Ki Summary

Reaction Details

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Target

Suppressor of tumorigenicity 14 protein

Ligand

BDBM50017925

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1364433 (CHEMBL3294545)

824±n/a nM

Citation

Goswami, R; Mukherjee, S; Ghadiyaram, C; Wohlfahrt, G; Sistla, RK; Nagaraj, J; Satyam, LK; Subbarao, K; Palakurthy, RK; Gopinath, S; Krishnamurthy, NR; Ikonen, T; Moilanen, A; Subramanya, HS; Kallio, P; Ramachandra, M Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy. Bioorg Med Chem22:3187-203 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Suppressor of tumorigenicity 14 protein

Name:

Suppressor of tumorigenicity 14 protein

Synonyms:

Type:

Single-pass type II membrane protein

Mol. Mass.:

94769.23

Organism:

Homo sapiens (Human)

Description:

Q9Y5Y6

Residue:

855

Sequence:

MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAA
VLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKV
KDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHLVEEAERVMAEERVVM
LPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPA
HARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPS
YNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHY
PPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTS
NSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDH
SDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSK
SQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK
DCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYID
DRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP
AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL
PQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYT
RLPLFRDWIKENTGV

BDBM50017925

n/a

Name

BDBM50017925

Synonyms:

CHEMBL3289041

Type

Small organic molecule

Emp. Form.

C27H29N5O4

Mol. Mass.

487.5503

SMILES

N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(Oc2ccc(cc2)C(N)=N)cc(Oc2ccc(cc2)C(N)=O)c1 |r,wU:4.7,wD:1.0,(15.46,-14.03,;14.12,-13.26,;14.12,-11.72,;12.79,-10.95,;11.46,-11.72,;11.46,-13.26,;12.79,-14.03,;10.12,-10.95,;8.79,-11.72,;8.79,-13.26,;7.46,-10.95,;6.12,-11.72,;4.79,-10.95,;3.45,-11.72,;2.12,-10.95,;.79,-11.72,;-.55,-10.95,;-.55,-9.41,;.79,-8.64,;2.12,-9.41,;-1.88,-8.64,;-3.21,-9.41,;-1.88,-7.1,;4.79,-9.41,;6.12,-8.64,;6.12,-7.1,;7.46,-6.33,;7.46,-4.79,;8.79,-4.02,;10.12,-4.79,;10.12,-6.33,;8.79,-7.1,;11.46,-4.02,;12.79,-4.79,;11.46,-2.48,;7.46,-9.41,)|

Structure