Reaction Details | |||
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Target | Suppressor of tumorigenicity 14 protein | ||
Ligand | BDBM50017904 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1364433 (CHEMBL3294545) | ||
Ki | 545±n/a nM | ||
Citation | Goswami, R; Mukherjee, S; Ghadiyaram, C; Wohlfahrt, G; Sistla, RK; Nagaraj, J; Satyam, LK; Subbarao, K; Palakurthy, RK; Gopinath, S; Krishnamurthy, NR; Ikonen, T; Moilanen, A; Subramanya, HS; Kallio, P; Ramachandra, M Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy. Bioorg Med Chem22:3187-203 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Suppressor of tumorigenicity 14 protein | |||
Name: | Suppressor of tumorigenicity 14 protein | ||
Synonyms: | Epithin | Hepatocyte growth factor activator/Serine protease hepsin/Suppressor of tumorigenicity 14 protein | MT-SP1 | Membrane-type serine protease 1 | PRSS14 | Prostamin | SNC19 | ST14 | ST14_HUMAN | Serine protease TADG-15 | Suppressor of tumorigenicity 14 protein | Suppressor of tumorigenicity protein 14 | TADG15 | ||
Type: | Single-pass type II membrane protein | ||
Mol. Mass.: | 94769.23 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9Y5Y6 | ||
Residue: | 855 | ||
Sequence: |
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BDBM50017904 | |||
n/a | |||
Name | BDBM50017904 | ||
Synonyms: | CHEMBL3289031 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H31N5O3 | ||
Mol. Mass. | 485.5774 | ||
SMILES | CC1CCC(CC1)C(=O)Nc1cc(Oc2ccc(cc2)C(N)=N)cc(Oc2ccc(cc2)C(N)=N)c1 |(17.03,-2.01,;17.03,-3.55,;15.69,-4.32,;15.69,-5.86,;17.03,-6.63,;18.36,-5.86,;18.36,-4.32,;17.03,-8.17,;18.36,-8.94,;15.69,-8.94,;14.36,-8.17,;14.36,-6.63,;13.03,-5.86,;13.03,-4.32,;11.69,-3.55,;11.69,-2.01,;10.36,-1.24,;9.03,-2.01,;9.03,-3.55,;10.36,-4.32,;7.69,-1.24,;6.36,-2.01,;7.69,.3,;11.69,-6.63,;11.69,-8.17,;10.36,-8.94,;9.03,-8.17,;7.69,-8.94,;6.36,-8.17,;6.36,-6.63,;7.69,-5.86,;9.03,-6.63,;5.02,-5.86,;3.69,-6.63,;5.02,-4.32,;13.03,-8.94,)| | ||
Structure |