| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor RXR-alpha |
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| Ligand | BDBM50018001 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1365631 (CHEMBL3297478) |
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| EC50 | >1000±n/a nM |
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| Citation |  Atigadda, VR; Xia, G; Desphande, A; Boerma, LJ; Lobo-Ruppert, S; Grubbs, CJ; Smith, CD; Brouillette, WJ; Muccio, DD Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity. J Med Chem57:5370-80 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoic acid receptor RXR-alpha |
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| Name: | Retinoic acid receptor RXR-alpha |
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| Synonyms: | NR2B Channel Blocker | Nr2b1 | RXRA_RAT | Retinoic acid receptor RXR-alpha | Retinoid X receptor alpha | Rxra |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51273.78 |
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| Organism: | RAT |
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| Description: | NR2B Channel Blocker 0 RAT::Q05343 |
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| Residue: | 467 |
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| Sequence: | MDTKHFLPLDFSTQVNSSSLSSPTGRGSMAAPSLHPSLGPGLGSPLGSPGQLHSPISTLS
SPINGMGPPFSVISSPMGPHSMSVPTTPTLGFETGSPQLNSPMNPVSSSEDIKPPLGLNG
VLKVPAHPSGNMSSFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNK
DCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVEKI
LEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLD
DQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVS
KMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRF
AKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQTT
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| BDBM50018001 |
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| n/a |
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| Name | BDBM50018001 |
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| Synonyms: | CHEMBL3289659 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24O2 |
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| Mol. Mass. | 308.4141 |
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| SMILES | C/C(/C=C/C=C(/C)\C=C1/CCCc2ccc(C)cc12)=C\C(O)=O |
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| Structure | 
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