| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
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| Ligand | BDBM50240464 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1364075 (CHEMBL3291754) |
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| Kd | 120000±n/a nM |
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| Citation |  Jia, Y; Kim, JH; Nam, B; Kim, J; Lee, JH; Hwang, KY; Lee, SJ The dipeptide H-Trp-Glu-OH (WE) shows agonistic activity to peroxisome proliferator-activated protein-a and reduces hepatic lipid accumulation in lipid-loaded H4IIE cells. Bioorg Med Chem Lett24:2957-62 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor alpha |
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| Name: | Peroxisome proliferator-activated receptor alpha |
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| Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52222.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07869 |
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| Residue: | 468 |
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| Sequence: | MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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| BDBM50240464 |
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| n/a |
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| Name | BDBM50240464 |
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| Synonyms: | (S)-2-((S)-2-amino-3-(1H-indol-3-yl)propanamido)pentanedioic acid | (S)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-pentanedioic acid | 2-[2-Amino-3-(1H-indol-3-yl)-propionylamino]-pentanedioic acid | CHEMBL39176 | L-Tryptophan-L-glutamic acid | Trp-Glu |
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| Type | Small organic molecule |
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| Emp. Form. | C16H19N3O5 |
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| Mol. Mass. | 333.3392 |
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| SMILES | N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(O)=O |r| |
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| Structure | 
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