| Reaction Details |
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 | Report a problem with these data |
| Target | Catechol O-methyltransferase |
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| Ligand | BDBM50019332 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1362902 (CHEMBL3291944) |
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| Ki | 25000±n/a nM |
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| Citation |  Lanier, M; Ambrus, G; Cole, DC; Davenport, R; Ellery, J; Fosbeary, R; Jennings, AJ; Kadotani, A; Kamada, Y; Kamran, R; Matsumoto, S; Mizukami, A; Okubo, S; Okada, K; Saikatendu, K; Walsh, L; Wu, H; Hixon, MS A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT). J Med Chem57:5459-63 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Catechol O-methyltransferase |
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| Name: | Catechol O-methyltransferase |
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| Synonyms: | COMT | COMT_HUMAN | Catechol O-methyltransferase | Catechol O-methyltransferase (MB-COMT) |
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| Type: | Enzyme |
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| Mol. Mass.: | 30030.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21964 |
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| Residue: | 271 |
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| Sequence: | MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRIL
NHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCG
YSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKY
DVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFE
CTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
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| BDBM50019332 |
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| n/a |
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| Name | BDBM50019332 |
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| Synonyms: | CHEMBL3289431 |
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| Type | Small organic molecule |
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| Emp. Form. | C7H8N4 |
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| Mol. Mass. | 148.1652 |
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| SMILES | Cn1nccc1-c1cc[nH]n1 |
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| Structure | 
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