| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A1 |
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| Ligand | BDBM50019516 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1365788 (CHEMBL3296314) |
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| IC50 | 8000±n/a nM |
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| Citation |  Naik, M; Humnabadkar, V; Tantry, SJ; Panda, M; Narayan, A; Guptha, S; Panduga, V; Manjrekar, P; Jena, LK; Koushik, K; Shanbhag, G; Jatheendranath, S; Manjunatha, MR; Gorai, G; Bathula, C; Rudrapatna, S; Achar, V; Sharma, S; Ambady, A; Hegde, N; Mahadevaswamy, J; Kaur, P; Sambandamurthy, VK; Awasthy, D; Narayan, C; Ravishankar, S; Madhavapeddi, P; Reddy, J; Prabhakar, K; Saralaya, R; Chatterji, M; Whiteaker, J; McLaughlin, B; Chiarelli, LR; Riccardi, G; Pasca, MR; Binda, C; Neres, J; Dhar, N; Signorino-Gelo, F; McKinney, JD; Ramachandran, V; Shandil, R; Tommasi, R; Iyer, PS; Narayanan, S; Hosagrahara, V; Kavanagh, S; Dinesh, N; Ghorpade, SR 4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity. J Med Chem57:5419-34 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A1 |
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| Name: | Adenosine receptor A1 |
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| Synonyms: | A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 36520.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30542 |
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| Residue: | 326 |
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| Sequence: | MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD
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| BDBM50019516 |
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| n/a |
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| Name | BDBM50019516 |
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| Synonyms: | CHEMBL3291063 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20ClFN6O |
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| Mol. Mass. | 402.853 |
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| SMILES | [H][C@]12CC[C@]([H])(C[C@@H](C1)Nc1n[nH]c3ccc(F)cc13)N2C(=O)c1cnn(C)c1Cl |r,TLB:21:20:2.3:7.6.8,9:7:20:2.3| |
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| Structure | 
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