Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sterol O-acyltransferase 2 | ||
| Ligand | BDBM50020047 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1363767 (CHEMBL3294184) | ||
| IC50 | 5000±n/a nM | ||
| Citation |  Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett5:544-9 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sterol O-acyltransferase 2 | |||
| Name: | Sterol O-acyltransferase 2 | ||
| Synonyms: | ACACT2 | ACAT-2 | ACAT2 | Acetyl-CoA acetyltransferase, cytosolic | Acetyl-CoA transferase-like protein | Acyl coenzyme A:cholesterol acyltransferase 2 | Cholesterol acyltransferase 2 | Cytosolic acetoacetyl-CoA thiolase | SOAT2 | SOAT2_HUMAN | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 59912.75 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75908 | ||
| Residue: | 522 | ||
| Sequence: |
| ||
| BDBM50020047 | |||
| n/a | |||
| Name | BDBM50020047 | ||
| Synonyms: | CHEMBL3287864 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H32N2O4 | ||
| Mol. Mass. | 484.5861 | ||
| SMILES | CC1CN(C(=O)Nc2ccccc2)c2ccc(cc2O1)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:26.29,wD:29.33,(3.83,-10.05,;5.18,-10.79,;5.22,-12.33,;6.57,-13.07,;6.61,-14.61,;7.95,-15.34,;5.29,-15.41,;5.33,-16.94,;4.01,-17.74,;4.05,-19.28,;5.4,-20.01,;6.71,-19.21,;6.68,-17.68,;7.88,-12.27,;9.23,-13.01,;10.55,-12.21,;10.51,-10.67,;9.16,-9.93,;7.85,-10.73,;6.5,-9.99,;11.83,-9.87,;11.79,-8.33,;13.1,-7.53,;14.45,-8.27,;14.49,-9.81,;13.18,-10.61,;15.77,-7.47,;15.73,-5.93,;17.04,-5.13,;18.39,-5.87,;19.71,-5.07,;19.67,-3.53,;20.99,-2.73,;18.32,-2.79,;18.43,-7.41,;17.12,-8.21,)| | ||
| Structure | 
| ||