Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50020059 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1363772 (CHEMBL3294189) | ||
| IC50 | 170±n/a nM | ||
| Citation |  Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett5:544-9 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 56810.61 | ||
| Organism: | Mus musculus (mouse) | ||
| Description: | In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system. | ||
| Residue: | 498 | ||
| Sequence: |
| ||
| BDBM50020059 | |||
| n/a | |||
| Name | BDBM50020059 | ||
| Synonyms: | CHEMBL3287887 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H30N6O2 | ||
| Mol. Mass. | 494.5875 | ||
| SMILES | O=C(Nc1ccccc1)N1CCOc2cc(ccc12)-c1ccc(cc1)[C@H]1CC[C@H](Cc2nnn[nH]2)CC1 |r,wU:25.28,wD:28.32,(8.34,-16.89,;6.99,-16.15,;5.67,-16.95,;5.71,-18.49,;4.39,-19.28,;4.43,-20.82,;5.78,-21.56,;7.1,-20.75,;7.05,-19.22,;6.95,-14.61,;5.6,-13.87,;5.56,-12.33,;6.88,-11.53,;8.23,-12.27,;9.55,-11.47,;10.9,-12.21,;10.93,-13.75,;9.62,-14.55,;8.27,-13.81,;12.21,-11.41,;13.56,-12.15,;14.87,-11.35,;14.84,-9.81,;13.49,-9.07,;12.17,-9.87,;16.15,-9.01,;16.11,-7.47,;17.43,-6.67,;18.78,-7.41,;20.1,-6.61,;21.45,-7.34,;22.83,-6.68,;23.88,-7.79,;23.15,-9.14,;21.64,-8.86,;18.82,-8.95,;17.51,-9.75,)| | ||
| Structure | 
| ||