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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50020068 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1363771 (CHEMBL3294188) | ||
| IC50 | 1900±n/a nM | ||
| Citation |  Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett5:544-9 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM50020068 | |||
| n/a | |||
| Name | BDBM50020068 | ||
| Synonyms: | CHEMBL3287861 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H29N3O4 | ||
| Mol. Mass. | 471.5476 | ||
| SMILES | OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2n1)C(=O)Nc1ccccc1 |r,wU:7.10,wD:4.3,(22.48,-9.66,;20.94,-9.66,;20.17,-10.99,;20.17,-8.32,;18.63,-8.32,;17.86,-6.99,;16.32,-6.99,;15.55,-8.32,;16.32,-9.66,;17.86,-9.66,;14.01,-8.32,;13.24,-9.66,;11.7,-9.66,;10.93,-8.32,;11.7,-6.99,;13.24,-6.99,;9.39,-8.32,;8.62,-6.99,;7.08,-6.99,;6.31,-8.32,;4.77,-8.32,;4,-9.66,;4.77,-10.99,;6.31,-10.99,;7.08,-9.66,;8.62,-9.66,;4,-6.99,;4.77,-5.65,;2.46,-6.99,;1.69,-5.65,;.15,-5.65,;-.62,-4.32,;.15,-2.99,;1.69,-2.99,;2.46,-4.32,)| | ||
| Structure | 
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