Reaction Details | |||
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Target | Diacylglycerol O-acyltransferase 1 | ||
Ligand | BDBM50020078 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1363772 (CHEMBL3294189) | ||
IC50 | >10000±n/a nM | ||
Citation | Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett5:544-9 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Diacylglycerol O-acyltransferase 1 | |||
Name: | Diacylglycerol O-acyltransferase 1 | ||
Synonyms: | DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
Type: | Enzyme | ||
Mol. Mass.: | 56810.61 | ||
Organism: | Mus musculus (mouse) | ||
Description: | In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system. | ||
Residue: | 498 | ||
Sequence: |
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BDBM50020078 | |||
n/a | |||
Name | BDBM50020078 | ||
Synonyms: | CHEMBL3287858 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H30N2O4 | ||
Mol. Mass. | 470.5595 | ||
SMILES | OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1cccc2N(CCOc12)C(=O)Nc1ccccc1 |r,wU:7.10,wD:4.3,(19.28,3.4,;17.95,2.63,;16.62,3.4,;17.95,1.09,;16.62,.32,;15.28,1.09,;13.95,.32,;13.95,-1.22,;15.28,-1.99,;16.62,-1.22,;12.62,-1.99,;12.62,-3.53,;11.28,-4.3,;9.95,-3.53,;9.95,-1.99,;11.28,-1.22,;8.62,-4.3,;7.28,-3.53,;5.95,-4.3,;5.95,-5.84,;7.28,-6.61,;7.28,-8.15,;8.62,-8.92,;9.95,-8.15,;9.95,-6.61,;8.62,-5.84,;5.95,-8.92,;4.61,-8.15,;5.95,-10.46,;4.61,-11.23,;4.61,-12.77,;3.28,-13.54,;1.95,-12.77,;1.95,-11.23,;3.28,-10.46,)| | ||
Structure |