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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50020080 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1363772 (CHEMBL3294189) | ||
| IC50 | >10000±n/a nM | ||
| Citation |  Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett5:544-9 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 56810.61 | ||
| Organism: | Mus musculus (mouse) | ||
| Description: | In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system. | ||
| Residue: | 498 | ||
| Sequence: |
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| BDBM50020080 | |||
| n/a | |||
| Name | BDBM50020080 | ||
| Synonyms: | CHEMBL3287860 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H29N3O4 | ||
| Mol. Mass. | 471.5476 | ||
| SMILES | OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1cnc2N(CCOc2c1)C(=O)Nc1ccccc1 |r,wU:7.10,wD:4.3,(24.29,-5.34,;22.75,-5.34,;21.98,-6.68,;21.98,-4.01,;20.44,-4.01,;19.67,-2.68,;18.13,-2.68,;17.36,-4.01,;18.13,-5.34,;19.67,-5.34,;15.82,-4.01,;15.05,-5.34,;13.51,-5.34,;12.74,-4.01,;13.51,-2.68,;15.05,-2.68,;11.2,-4.01,;10.43,-2.68,;8.89,-2.68,;8.12,-4.01,;6.58,-4.01,;5.81,-5.34,;6.58,-6.68,;8.12,-6.68,;8.89,-5.34,;10.43,-5.34,;5.81,-2.68,;6.58,-1.34,;4.27,-2.68,;3.5,-1.34,;1.96,-1.34,;1.19,-.01,;1.96,1.33,;3.5,1.33,;4.27,-.01,)| | ||
| Structure | 
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