Reaction Details | |||
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Target | Diacylglycerol O-acyltransferase 1 | ||
Ligand | BDBM50020085 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1363771 (CHEMBL3294188) | ||
IC50 | 140±n/a nM | ||
Citation | Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett5:544-9 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Diacylglycerol O-acyltransferase 1 | |||
Name: | Diacylglycerol O-acyltransferase 1 | ||
Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
Type: | Protein | ||
Mol. Mass.: | 55297.82 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O75907 | ||
Residue: | 488 | ||
Sequence: |
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BDBM50020085 | |||
n/a | |||
Name | BDBM50020085 | ||
Synonyms: | CHEMBL3287877 | ||
Type | Small organic molecule | ||
Emp. Form. | C32H36N2O4 | ||
Mol. Mass. | 512.6392 | ||
SMILES | CC(C)c1ccccc1NC(=O)N1CCOc2cc(ccc12)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:28.31,wD:31.35,(4.62,-16.39,;4.66,-17.93,;3.34,-18.73,;6.01,-18.67,;6.04,-20.21,;7.39,-20.95,;8.71,-20.15,;8.68,-18.61,;7.32,-17.87,;7.29,-16.34,;8.61,-15.53,;9.95,-16.27,;8.57,-13.99,;7.22,-13.25,;7.18,-11.71,;8.5,-10.91,;9.85,-11.65,;11.16,-10.85,;12.52,-11.59,;12.55,-13.13,;11.24,-13.93,;9.88,-13.19,;13.83,-10.79,;13.79,-9.25,;15.11,-8.45,;16.46,-9.19,;16.5,-10.73,;15.18,-11.53,;17.78,-8.39,;17.74,-6.85,;19.06,-6.05,;20.41,-6.79,;21.72,-5.99,;21.69,-4.45,;23,-3.65,;20.33,-3.7,;20.44,-8.33,;19.13,-9.13,)| | ||
Structure |