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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 4-hydroxyphenylpyruvate dioxygenase | ||
| Ligand | BDBM50024725 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1438115 (CHEMBL3388490) | ||
| Ki | 24±n/a nM | ||
| Citation |  Xu, YL; Lin, HY; Cao, RJ; Ming, ZZ; Yang, WC; Yang, GF Pyrazolone-quinazolone hybrids: a novel class of human 4-hydroxyphenylpyruvate dioxygenase inhibitors. Bioorg Med Chem22:5194-211 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 4-hydroxyphenylpyruvate dioxygenase | |||
| Name: | 4-hydroxyphenylpyruvate dioxygenase | ||
| Synonyms: | 4-hydroxyphenylpyruvate dioxygenase | 4-hydroxyphenylpyruvic acid oxidase | 4HPPD | HPD | HPPD_HUMAN | PPD | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 44937.33 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_123 | ||
| Residue: | 393 | ||
| Sequence: |
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| BDBM50024725 | |||
| n/a | |||
| Name | BDBM50024725 | ||
| Synonyms: | CHEMBL3342599 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H15BrN4O3 | ||
| Mol. Mass. | 439.262 | ||
| SMILES | Cc1nc2ccc(cc2c(=O)n1-c1ccccc1Br)C(=O)c1cnn(C)c1O |(57.5,-6.26,;56.15,-5.52,;54.82,-6.32,;53.47,-5.58,;52.15,-6.37,;50.8,-5.63,;50.78,-4.08,;52.09,-3.29,;53.43,-4.03,;54.75,-3.22,;54.72,-1.68,;56.12,-3.97,;57.43,-3.17,;57.39,-1.63,;58.7,-.83,;60.06,-1.57,;60.09,-3.11,;58.78,-3.91,;58.81,-5.45,;49.43,-3.34,;49.4,-1.8,;48.11,-4.14,;47.98,-5.67,;46.48,-6.03,;45.69,-4.71,;44.15,-4.58,;46.69,-3.54,;46.33,-2.04,)| | ||
| Structure | 
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