| Reaction Details |
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 | Report a problem with these data |
| Target | Enoyl-[acyl-carrier-protein] reductase [NADH] |
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| Ligand | BDBM50026420 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1433044 (CHEMBL3385192) |
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| IC50 | 9060±n/a nM |
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| Citation |  Pedgaonkar, GS; Sridevi, JP; Jeankumar, VU; Saxena, S; Devi, PB; Renuka, J; Yogeeswari, P; Sriram, D Development of 2-(4-oxoquinazolin-3(4H)-yl)acetamide derivatives as novel enoyl-acyl carrier protein reductase (InhA) inhibitors for the treatment of tuberculosis. Eur J Med Chem86:613-27 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Enoyl-[acyl-carrier-protein] reductase [NADH] |
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| Name: | Enoyl-[acyl-carrier-protein] reductase [NADH] |
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| Synonyms: | Enoyl-ACP Reductase (InhA) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-[acyl-carrier-protein] reductase [NADH] | INHA_MYCTU | NADH-dependent enoyl-ACP reductase | inhA |
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| Type: | Enzyme |
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| Mol. Mass.: | 28526.00 |
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| Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
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| Description: | P9WGR1 |
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| Residue: | 269 |
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| Sequence: | MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPL
LELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGI
HISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAG
KYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAK
TVCALLSDWLPATTGDIIYADGGAHTQLL
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| BDBM50026420 |
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| n/a |
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| Name | BDBM50026420 |
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| Synonyms: | CHEMBL3331279 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16ClF2N3O2 |
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| Mol. Mass. | 391.799 |
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| SMILES | Cc1nc2ccccc2c(=O)n1CC(=O)Nc1cc(ccc1Cl)C(C)(F)F |
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| Structure | 
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