| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aurora kinase B |
|---|
| Ligand | BDBM50029454 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1436941 (CHEMBL3388439) |
|---|
| IC50 | 181±n/a nM |
|---|
| Citation |  Cai, J; Li, L; Hong, KH; Wu, X; Chen, J; Wang, P; Cao, M; Zong, X; Ji, M Discovery of 4-aminoquinazoline--urea derivatives as Aurora kinase inhibitors with antiproliferative activity. Bioorg Med Chem22:5813-23 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aurora kinase B |
|---|
| Name: | Aurora kinase B |
|---|
| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 39327.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96GD4 |
|---|
| Residue: | 344 |
|---|
| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
|
|
|
|---|
| BDBM50029454 |
|---|
| n/a |
|---|
| Name | BDBM50029454 |
|---|
| Synonyms: | CHEMBL3343418 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H38N6O2 |
|---|
| Mol. Mass. | 490.6403 |
|---|
| SMILES | O=C(NC1CCCCC1)Nc1ccc(NC2=NC=NC3C=C(OCCCN4CCCC4)C=CC23)cc1 |c:18,33,t:16,21| |
|---|
| Structure | 
|
|---|
Search and Browse
