| Reaction Details |
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 | Report a problem with these data |
| Target | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
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| Ligand | BDBM81939 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1437089 (CHEMBL3381103) |
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| EC50 | 37300±n/a nM |
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| Citation |  Krauze, A; Grinberga, S; Krasnova, L; Adlere, I; Sokolova, E; Domracheva, I; Shestakova, I; Andzans, Z; Duburs, G Thieno[2,3-b]pyridines--a new class of multidrug resistance (MDR) modulators. Bioorg Med Chem22:5860-70 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Broad substrate specificity ATP-binding cassette transporter ABCG2 |
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| Name: | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
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| Synonyms: | ABCG2 | ABCG2_HUMAN | ABCP | ATP-Binding Cassette Transporter ABCG2 | ATP-binding cassette sub-family G member 2 | ATP-binding cassette transporter (ABCG2) | ATP-binding cassette, sub-family G, member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | MXR | Mitoxantrone resistance-associated protein | Placenta-specific ATP-binding cassette transporter | Urate exporter |
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| Type: | Multi-pass membrane protein; monomer or homodimer; disulfide-linked |
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| Mol. Mass.: | 72329.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UNQ0 |
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| Residue: | 655 |
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| Sequence: | MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE
KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN
SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT
QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF
SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING
DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK
ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS
TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP
MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL
MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN
NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
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| BDBM81939 |
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| n/a |
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| Name | BDBM81939 |
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| Synonyms: | CAS_52-53-9 | NSC_62969 | VERAPAMIL |
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| Type | Small organic molecule |
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| Emp. Form. | C27H38N2O4 |
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| Mol. Mass. | 454.6016 |
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| SMILES | COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC |
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| Structure | 
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