Reaction Details |
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Target | Dihydropteroate synthase |
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Ligand | BDBM50031526 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1440910 (CHEMBL3375174) |
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Kd | 8400±n/a nM |
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Citation | Dennis, ML; Chhabra, S; Wang, ZC; Debono, A; Dolezal, O; Newman, J; Pitcher, NP; Rahmani, R; Cleary, B; Barlow, N; Hattarki, M; Graham, B; Peat, TS; Baell, JB; Swarbrick, JD Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus. J Med Chem57:9612-26 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydropteroate synthase |
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Name: | Dihydropteroate synthase |
Synonyms: | Bacterial dihydropteroate synthase | DHPS_ECOLI | Dihydropteroate synthase | dhpS | folP |
Type: | PROTEIN |
Mol. Mass.: | 30611.24 |
Organism: | Escherichia coli (strain K12) |
Description: | ChEMBL_1440910 |
Residue: | 282 |
Sequence: | MKLFAQGTSLDLSHPHVMGILNVTPDSFSDGGTHNSLIDAVKHANLMINAGATIIDVGGE
STRPGAAEVSVEEELQRVIPVVEAIAQRFEVWISVDTSKPEVIRESAKVGAHIINDIRSL
SEPGALEAAAETGLPVCLMHMQGNPKTMQEAPKYDDVFAEVNRYFIEQIARCEQAGIAKE
KLLLDPGFGFGKNLSHNYSLLARLAEFHHFNLPLLVGMSRKSMIGQLLNVGPSERLSGSL
ACAVIAAMQGAHIIRVHDVKETVEAMRVVEATLSAKENKRYE
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BDBM50031526 |
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n/a |
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Name | BDBM50031526 |
Synonyms: | CHEMBL3359158 |
Type | Small organic molecule |
Emp. Form. | C19H15N5O2S |
Mol. Mass. | 377.42 |
SMILES | Nc1nc2[nH]c(SCC(=O)c3ccc(cc3)-c3ccccc3)nc2c(=O)[nH]1 |
Structure |
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