| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Ligand | BDBM50032550 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1440940 (CHEMBL3375790) |
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| IC50 | 12±n/a nM |
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| Citation |  Kawai, K; Endo, Y; Asano, T; Amano, S; Sawada, K; Ueo, N; Takahashi, N; Sonoda, Y; Nagai, M; Kamei, N; Nagata, N Discovery of 2-(cyclopentylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as a new series of potent phosphodiesterase 7 inhibitors. J Med Chem57:9844-54 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55514.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13946 |
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| Residue: | 482 |
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| Sequence: | MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
LS
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| BDBM50032550 |
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| n/a |
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| Name | BDBM50032550 |
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| Synonyms: | CHEMBL3354182 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H31N5O4S |
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| Mol. Mass. | 461.578 |
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| SMILES | CCn1c(NC2CCCC2)nc2c(csc2c1=O)N1CCN(CC1=O)C(=O)OC(C)(C)C |
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| Structure | 
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