Reaction Details |
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Target | Transmembrane protease serine 6 |
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Ligand | BDBM50032709 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1442547 (CHEMBL3371671) |
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Ki | 2.5±n/a nM |
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Citation | Duchêne, D; Colombo, E; Désilets, A; Boudreault, PL; Leduc, R; Marsault, E; Najmanovich, R Analysis of subpocket selectivity and identification of potent selective inhibitors for matriptase and matriptase-2. J Med Chem57:10198-204 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Transmembrane protease serine 6 |
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Name: | Transmembrane protease serine 6 |
Synonyms: | Matriptase-2 | TMPRSS6 | TMPS6_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 90001.12 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1442547 |
Residue: | 811 |
Sequence: | MLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLL
ALLVLASAGVLLWYFLGYKAEVMVSQVYSGSLRVLNRHFSQDLTRRESSAFRSETAKAQK
MLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEELL
STVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDH
LASSCLWHLQGPKDLMLKLRLEWTLAECRDRLAMYDVAGPLEKRLITSVYGCSRQEPVVE
VLASGAIMAVVWKKGLHSYYDPFVLSVQPVVFQACEVNLTLDNRLDSQGVLSTPYFPSYY
SPQTHCSWHLTVPSLDYGLALWFDAYALRRQKYDLPCTQGQWTIQNRRLCGLRILQPYAE
RIPVVATAGITINFTSQISLTGPGVRVHYGLYNQSDPCPGEFLCSVNGLCVPACDGVKDC
PNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCED
RSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRH
ICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYH
EEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPISNAL
QKVDVQLIPQDLCSEVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGL
VSWGLGCGRPNYFGVYTRITGVISWIQQVVT
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BDBM50032709 |
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n/a |
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Name | BDBM50032709 |
Synonyms: | CHEMBL3354686 |
Type | Small organic molecule |
Emp. Form. | C28H45N11O5S |
Mol. Mass. | 647.793 |
SMILES | CC(C)C[C@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r| |
Structure |
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