Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMatriptase
LigandBDBM50032991
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1432691
Ki 1.1±n/a nM
Citation Han ZHarris PKJones DEChugani RKim TAgarwal MShen WWildman SAJanetka JW Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer. ACS Med Chem Lett 5:1219-24 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Matriptase
Name:Hepatocyte growth factor activator/Serine protease hepsin/Suppressor of tumorigenicity 14 protein
Synonyms:Epithin | MT-SP1 | Membrane-type serine protease 1 | Prostamin | ST14 | Serine protease TADG-15 | Suppressor of tumorigenicity 14 protein | Suppressor of tumorigenicity protein 14
Type:Single-pass type II membrane protein
Mol. Mass.:94769.23
Organism:Homo sapiens (Human)
Description:n/a
Residue:855
Sequence:
MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAA
VLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKV
KDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHLVEEAERVMAEERVVM
LPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPA
HARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPS
YNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHY
PPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTS
NSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDH
SDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSK
SQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK
DCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYID
DRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP
AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL
PQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYT
RLPLFRDWIKENTGV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50032991
n/a
NameBDBM50032991
Synonyms:CHEMBL3356596
TypeSmall organic molecule
Emp. Form.C29H52N12O5S
Mol. Mass.680.866
SMILESCC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nccs1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: