| Reaction Details |
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 | Report a problem with these data |
| Target | Matrix metalloproteinase-17 |
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| Ligand | BDBM50035472 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1441830 (CHEMBL3380041) |
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| IC50 | 3260±n/a nM |
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| Citation |  Matusiak, N; Castelli, R; Tuin, AW; Overkleeft, HS; Wisastra, R; Dekker, FJ; Prély, LM; Bischoff, R; Bischoff, RP; van Waarde, A; Dierckx, RA; Elsinga, PH A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [¹8F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging. Bioorg Med Chem23:192-202 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Matrix metalloproteinase-17 |
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| Name: | Matrix metalloproteinase-17 |
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| Synonyms: | MMP-17 | MMP17 | MMP17_HUMAN | MT-MMP 4 | MT4-MMP | MT4MMP | MTMMP4 | Matrix metalloproteinase 17 | Matrix metalloproteinase-17 | Membrane-type matrix metalloproteinase 4 | Membrane-type-4 matrix metalloproteinase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66652.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1433225 |
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| Residue: | 603 |
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| Sequence: | MRRRAARGPGPPPPGPGLSRLPLPLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFG
YLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQ
ARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAG
SAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGM
DLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESV
SPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRD
RHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRP
VSDFSLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLD
DAMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTARDWLVCGDSQADGSVAAGVDAAE
GPRAPPGQHDQSRSEDGYEVCSCTSGASSPPGAPGPLVAATMLLLLPPLSPGALWTAAQA
LTL
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| BDBM50035472 |
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| n/a |
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| Name | BDBM50035472 |
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| Synonyms: | CHEMBL3355724 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H43F2N5O7 |
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| Mol. Mass. | 707.7634 |
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| SMILES | CC(C)C[C@H](CC(=O)NOC(=O)c1ccc(F)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCNC(=O)c1ccc(F)cc1)C(N)=O |r| |
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| Structure | 
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