| Reaction Details |
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 | Report a problem with these data |
| Target | Hexokinase-4 |
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| Ligand | BDBM50041606 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1445934 (CHEMBL3377918) |
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| EC50 | 14±n/a nM |
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| Citation |  Du, X; Hinklin, RJ; Xiong, Y; Dransfield, P; Park, J; Kohn, TJ; Pattaropong, V; Lai, S; Fu, Z; Jiao, X; Chow, D; Jin, L; Davda, J; Veniant, MM; Anderson, DA; Baer, BR; Bencsik, JR; Boyd, SA; Chicarelli, MJ; Mohr, PJ; Wang, B; Condroski, KR; DeWolf, WE; Conn, M; Tran, T; Yang, J; Aicher, TD; Medina, JC; Coward, P; Houze, JB C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators. ACS Med Chem Lett5:1284-9 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hexokinase-4 |
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| Name: | Hexokinase-4 |
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| Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
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| Type: | Enzyme |
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| Mol. Mass.: | 52175.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35557 |
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| Residue: | 465 |
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| Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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| BDBM50041606 |
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| n/a |
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| Name | BDBM50041606 |
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| Synonyms: | CHEMBL3358432 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H28N4O2 |
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| Mol. Mass. | 368.4726 |
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| SMILES | CCc1ncccc1Oc1cc(CC2CCCCC2)cnc1NC(=O)NC |
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| Structure | 
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