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Compile Data Set for Download or QSAR

Found 6476 hits with Last Name = 'hinklin' and Initial = 'rj'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GTPase KRas


(Homo sapiens (Human))
BDBM50539763
PNG
(Adagrasib | Mrtx-849 | Mrtx849)
Show SMILES CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C(F)=C)c1cccc2cccc(Cl)c12
Show InChI InChI=1S/C32H35ClFN7O2/c1-21(34)31(42)41-17-16-40(18-23(41)11-13-35)30-25-12-15-39(28-10-4-7-22-6-3-9-26(33)29(22)28)19-27(25)36-32(37-30)43-20-24-8-5-14-38(24)2/h3-4,6-7,9-10,23-24H,1,5,8,11-12,14-20H2,2H3/t23-,24-/m0/s1
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3.70E+3n/an/an/an/an/an/an/an/a



Array BioPharma Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant KRAS G12C mutant (unknown origin) assessed as rate of inactivation by LC-MS analysis


J Med Chem 63: 6679-6693 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02052
BindingDB Entry DOI: 10.7270/Q2G164C5
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [F1200I]


(Homo sapiens (Human))
BDBM517033
PNG
((R)-N-(3-fluoro-4-((3- ((1-hydroxypropan-2- yl)ami...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cc(C)cn(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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TBA

Assay Description
The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230C]


(Homo sapiens (Human))
BDBM517033
PNG
((R)-N-(3-fluoro-4-((3- ((1-hydroxypropan-2- yl)ami...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cc(C)cn(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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TBA

Assay Description
The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230C]


(Homo sapiens (Human))
BDBM517030
PNG
((R)-N-(3-fluoro-4-((3- ((1-hydroxypropan-2- yl)ami...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4ccc(C)n(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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Assay Description
The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230S]


(Homo sapiens (Human))
BDBM517051
PNG
((R)-5-bromo-N-(3- fluoro-4-((3-((1- hydroxypropan-...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cc(Br)cn(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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Assay Description
The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230S]


(Homo sapiens (Human))
BDBM517033
PNG
((R)-N-(3-fluoro-4-((3- ((1-hydroxypropan-2- yl)ami...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cc(C)cn(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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Assay Description
The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM517033
PNG
((R)-N-(3-fluoro-4-((3- ((1-hydroxypropan-2- yl)ami...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cc(C)cn(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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Assay Description
The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [1-13,15-1390]


(Homo sapiens (Human))
BDBM517033
PNG
((R)-N-(3-fluoro-4-((3- ((1-hydroxypropan-2- yl)ami...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cc(C)cn(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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Assay Description
The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [1-13,15-1390]


(Homo sapiens (Human))
BDBM517021
PNG
((R)-1-cyclobutyl-N-(3- fluoro-4-((3-((1- hydroxypr...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cn(C5CCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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Assay Description
The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230S]


(Homo sapiens (Human))
BDBM517002
PNG
((R)—N-(3-fluoro-4-((3-((1-hydroxypropan-2-yl)amino...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cn(C(C)C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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Assay Description
The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [1-13,15-1390]


(Homo sapiens (Human))
BDBM517014
PNG
((R)-1- (cyclopropylmethyl)-N- (3-fluoro-4-((3-((1-...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cn(CC5CC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
GTPase KRas


(Homo sapiens (Human))
BDBM50539762
PNG
(CHEMBL4632935)
Show SMILES CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C=C)c1cccc2cccc(C)c12 |r|
Show InChI InChI=1S/C33H39N7O2/c1-4-30(41)40-19-18-39(20-25(40)13-15-34)32-27-14-17-38(29-12-6-10-24-9-5-8-23(2)31(24)29)21-28(27)35-33(36-32)42-22-26-11-7-16-37(26)3/h4-6,8-10,12,25-26H,1,7,11,13-14,16-22H2,2-3H3/t25-,26-/m0/s1
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Array BioPharma Inc

Curated by ChEMBL


Assay Description
Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western method


J Med Chem 63: 6679-6693 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02052
BindingDB Entry DOI: 10.7270/Q2G164C5
More data for this
Ligand-Target Pair
GTPase KRas


(Homo sapiens (Human))
BDBM50539761
PNG
(CHEMBL4648852)
Show SMILES CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C=C)c1cccc2cccc(Cl)c12 |r|
Show InChI InChI=1S/C32H36ClN7O2/c1-3-29(41)40-18-17-39(19-23(40)12-14-34)31-25-13-16-38(28-11-5-8-22-7-4-10-26(33)30(22)28)20-27(25)35-32(36-31)42-21-24-9-6-15-37(24)2/h3-5,7-8,10-11,23-24H,1,6,9,12-13,15-21H2,2H3/t23-,24-/m0/s1
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Array BioPharma Inc

Curated by ChEMBL


Assay Description
Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western method


J Med Chem 63: 6679-6693 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02052
BindingDB Entry DOI: 10.7270/Q2G164C5
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM517051
PNG
((R)-5-bromo-N-(3- fluoro-4-((3-((1- hydroxypropan-...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cc(Br)cn(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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Assay Description
The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230C]


(Homo sapiens (Human))
BDBM517021
PNG
((R)-1-cyclobutyl-N-(3- fluoro-4-((3-((1- hydroxypr...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cn(C5CCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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Assay Description
The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230C]


(Homo sapiens (Human))
BDBM516997
PNG
((R)-N-(3-fluoro-4-((3- ((1-hydroxybutan-2- yl)amin...)
Show SMILES CC[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cn(C(C)C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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Assay Description
The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM517030
PNG
((R)-N-(3-fluoro-4-((3- ((1-hydroxypropan-2- yl)ami...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4ccc(C)n(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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Assay Description
The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230H]


(Homo sapiens (Human))
BDBM517021
PNG
((R)-1-cyclobutyl-N-(3- fluoro-4-((3-((1- hydroxypr...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cn(C5CCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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Assay Description
The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM516967
PNG
(N-(3-fluoro-4-((3- (((1s,3s)-3- (hydroxymethyl)cyc...)
Show SMILES OC[C@H]1CC(C1)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4ccnn(-c5ccc(F)cc5)c4=O)cc3F)c12 |r,wU:2.1,(-12.34,2.12,;-11.94,.63,;-10.45,.23,;-9.12,1,;-8.35,-.33,;-9.68,-1.1,;-6.86,-.73,;-6.46,-2.22,;-7.37,-3.47,;-6.46,-4.71,;-5,-4.23,;-3.67,-5,;-2.33,-4.23,;-2.33,-2.69,;-3.67,-1.93,;-3.67,-.38,;-2.33,.38,;-1,-.38,;.34,.38,;.34,1.93,;1.67,2.69,;3,1.93,;3,.38,;4.34,2.69,;4.34,4.23,;5.67,5,;7,4.23,;7,2.69,;8.34,1.93,;8.34,.38,;9.67,-.38,;11.01,.38,;12.34,-.38,;11.01,1.93,;9.67,2.69,;5.67,1.93,;5.67,.38,;-1,2.69,;-2.33,1.93,;-3.67,2.69,;-5,-2.69,)|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230S]


(Homo sapiens (Human))
BDBM517032
PNG
((R)-N-(3-fluoro-4-((3- ((1-hydroxypropan-2- yl)ami...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4c(C)ccn(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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Assay Description
The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230H]


(Homo sapiens (Human))
BDBM517014
PNG
((R)-1- (cyclopropylmethyl)-N- (3-fluoro-4-((3-((1-...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cn(CC5CC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230C]


(Homo sapiens (Human))
BDBM517002
PNG
((R)—N-(3-fluoro-4-((3-((1-hydroxypropan-2-yl)amino...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cn(C(C)C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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Assay Description
The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM517021
PNG
((R)-1-cyclobutyl-N-(3- fluoro-4-((3-((1- hydroxypr...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cn(C5CCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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Assay Description
The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230S]


(Homo sapiens (Human))
BDBM517049
PNG
((R)-5-cyclopropyl-N-(3- fluoro-4-((3-((1- hydroxyp...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cc(cn(-c5ccc(F)cc5)c4=O)C4CC4)cc3F)c12 |r|
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Assay Description
The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM516958
PNG
(N-(3-fluoro-4-((3-((cis- 2-(methoxymethyl) cyclope...)
Show SMILES COC[C@@H]1CCCC1Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4ccnn(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230S]


(Homo sapiens (Human))
BDBM517030
PNG
((R)-N-(3-fluoro-4-((3- ((1-hydroxypropan-2- yl)ami...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4ccc(C)n(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


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BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230C]


(Homo sapiens (Human))
BDBM517038
PNG
((R)-N-(3-fluoro-4-((3- ((1-hydroxypropan-2- yl)ami...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4nn(C(C)C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [1-13,15-1390]


(Homo sapiens (Human))
BDBM517030
PNG
((R)-N-(3-fluoro-4-((3- ((1-hydroxypropan-2- yl)ami...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4ccc(C)n(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM517078
PNG
((S)-1-ethyl-N-(3-fluoro- 4-((3-((1- methoxypropan-...)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3ccnc4[nH]nc(N[C@@H](C)COC)c34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


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BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230S]


(Homo sapiens (Human))
BDBM517014
PNG
((R)-1- (cyclopropylmethyl)-N- (3-fluoro-4-((3-((1-...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cn(CC5CC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [F1200I]


(Homo sapiens (Human))
BDBM516967
PNG
(N-(3-fluoro-4-((3- (((1s,3s)-3- (hydroxymethyl)cyc...)
Show SMILES OC[C@H]1CC(C1)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4ccnn(-c5ccc(F)cc5)c4=O)cc3F)c12 |r,wU:2.1,(-12.34,2.12,;-11.94,.63,;-10.45,.23,;-9.12,1,;-8.35,-.33,;-9.68,-1.1,;-6.86,-.73,;-6.46,-2.22,;-7.37,-3.47,;-6.46,-4.71,;-5,-4.23,;-3.67,-5,;-2.33,-4.23,;-2.33,-2.69,;-3.67,-1.93,;-3.67,-.38,;-2.33,.38,;-1,-.38,;.34,.38,;.34,1.93,;1.67,2.69,;3,1.93,;3,.38,;4.34,2.69,;4.34,4.23,;5.67,5,;7,4.23,;7,2.69,;8.34,1.93,;8.34,.38,;9.67,-.38,;11.01,.38,;12.34,-.38,;11.01,1.93,;9.67,2.69,;5.67,1.93,;5.67,.38,;-1,2.69,;-2.33,1.93,;-3.67,2.69,;-5,-2.69,)|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230C]


(Homo sapiens (Human))
BDBM516967
PNG
(N-(3-fluoro-4-((3- (((1s,3s)-3- (hydroxymethyl)cyc...)
Show SMILES OC[C@H]1CC(C1)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4ccnn(-c5ccc(F)cc5)c4=O)cc3F)c12 |r,wU:2.1,(-12.34,2.12,;-11.94,.63,;-10.45,.23,;-9.12,1,;-8.35,-.33,;-9.68,-1.1,;-6.86,-.73,;-6.46,-2.22,;-7.37,-3.47,;-6.46,-4.71,;-5,-4.23,;-3.67,-5,;-2.33,-4.23,;-2.33,-2.69,;-3.67,-1.93,;-3.67,-.38,;-2.33,.38,;-1,-.38,;.34,.38,;.34,1.93,;1.67,2.69,;3,1.93,;3,.38,;4.34,2.69,;4.34,4.23,;5.67,5,;7,4.23,;7,2.69,;8.34,1.93,;8.34,.38,;9.67,-.38,;11.01,.38,;12.34,-.38,;11.01,1.93,;9.67,2.69,;5.67,1.93,;5.67,.38,;-1,2.69,;-2.33,1.93,;-3.67,2.69,;-5,-2.69,)|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


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BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230C]


(Homo sapiens (Human))
BDBM517047
PNG
((S)-N-(3-fluoro-4-((3- ((1-hydroxypropan-2- yl)ami...)
Show SMILES C[C@@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cn(C)cc(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230S]


(Homo sapiens (Human))
BDBM517047
PNG
((S)-N-(3-fluoro-4-((3- ((1-hydroxypropan-2- yl)ami...)
Show SMILES C[C@@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cn(C)cc(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


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BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM517038
PNG
((R)-N-(3-fluoro-4-((3- ((1-hydroxypropan-2- yl)ami...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4nn(C(C)C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM517034
PNG
((R)-N-(3-fluoro-4-((3- ((1-hydroxypropan-2- yl)ami...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4nccn(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM517032
PNG
((R)-N-(3-fluoro-4-((3- ((1-hydroxypropan-2- yl)ami...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4c(C)ccn(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM517022
PNG
((R)-3-(3,4- difluorophenyl)-N-(3- fluoro-4-((3-((1...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cn(C(C)C)c(=O)n(-c5ccc(F)c(F)c5)c4=O)cc3F)c12 |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230C]


(Homo sapiens (Human))
BDBM516975
PNG
(N-(4-((3-((1,3- dihydroxypropan-2- yl)amino)-1H- p...)
Show SMILES OCC(CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4ccnn(-c5ccc(F)cc5)c4=O)cc3F)c12
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [D1228N]


(Homo sapiens (Human))
BDBM517032
PNG
((R)-N-(3-fluoro-4-((3- ((1-hydroxypropan-2- yl)ami...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4c(C)ccn(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [F1200I]


(Homo sapiens (Human))
BDBM517030
PNG
((R)-N-(3-fluoro-4-((3- ((1-hydroxypropan-2- yl)ami...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4ccc(C)n(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230S]


(Homo sapiens (Human))
BDBM517078
PNG
((S)-1-ethyl-N-(3-fluoro- 4-((3-((1- methoxypropan-...)
Show SMILES CCn1cc(C(=O)Nc2ccc(Oc3ccnc4[nH]nc(N[C@@H](C)COC)c34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230S]


(Homo sapiens (Human))
BDBM517011
PNG
((S)-N-(3-fluoro-4-((3- ((3-hydroxy-3- methylbutan-...)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc4[nH]nc(N[C@@H](C)C(C)(C)O)c34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [F1200I]


(Homo sapiens (Human))
BDBM516997
PNG
((R)-N-(3-fluoro-4-((3- ((1-hydroxybutan-2- yl)amin...)
Show SMILES CC[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cn(C(C)C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [F1200I]


(Homo sapiens (Human))
BDBM516975
PNG
(N-(4-((3-((1,3- dihydroxypropan-2- yl)amino)-1H- p...)
Show SMILES OCC(CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4ccnn(-c5ccc(F)cc5)c4=O)cc3F)c12
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


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BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [F1200I]


(Homo sapiens (Human))
BDBM517047
PNG
((S)-N-(3-fluoro-4-((3- ((1-hydroxypropan-2- yl)ami...)
Show SMILES C[C@@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cn(C)cc(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


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BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [Y1230C]


(Homo sapiens (Human))
BDBM517051
PNG
((R)-5-bromo-N-(3- fluoro-4-((3-((1- hydroxypropan-...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cc(Br)cn(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


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BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM516964
PNG
(N-(3-fluoro-4-((3-((3- hydroxy-3-methylbutan-2- yl...)
Show SMILES CC(Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4ccnn(-c5ccc(F)cc5)c4=O)cc3F)c12)C(C)(C)O
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


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BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM517037
PNG
((R)-N-(3-fluoro-4-((3- ((1-hydroxypropan-2- yl)ami...)
Show SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4nn(C(C)C)c(=S)n(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
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The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


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BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM517090
PNG
((R)-N-(3-fluoro-4-((3- ((1-methoxypropan-2- yl)ami...)
Show SMILES COC[C@@H](C)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4ccc(C)n(-c5ccc(F)cc5)c4=O)cc3F)c12 |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 1.5n/an/an/an/an/an/a


TBA

Assay Description
The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BZ6962
More data for this
Ligand-Target Pair
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