| Reaction Details |
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 | Report a problem with these data |
| Target | Glucocorticoid receptor |
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| Ligand | BDBM50041896 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1446342 (CHEMBL3374308) |
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| IC50 | 600±n/a nM |
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| Citation |  Harcken, C; Riether, D; Liu, P; Razavi, H; Patel, U; Lee, T; Bosanac, T; Ward, Y; Ralph, M; Chen, Z; Souza, D; Nelson, RM; Kukulka, A; Fadra-Khan, TN; Zuvela-Jelaska, L; Patel, M; Thomson, DS; Nabozny, GH Optimization of drug-like properties of nonsteroidal glucocorticoid mimetics and identification of a clinical candidate. ACS Med Chem Lett5:1318-23 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucocorticoid receptor |
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| Name: | Glucocorticoid receptor |
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| Synonyms: | GCR_MOUSE | Glucocorticoid | Glucocorticoid receptor | Grl | Grl1 | Nr3c1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 86050.26 |
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| Organism: | MOUSE |
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| Description: | Glucocorticoid 0 MOUSE::P06537 |
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| Residue: | 783 |
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| Sequence: | MDSKESLAPPGRDEVPSSLLGRGRGSVMDLYKTLRGGATVKVSASSPSVAAASQADSKQQ
RILLDFSKGSASNAQQQQQQQQPQPDLSKAVSLSMGLYMGETETKVMGNDLGYPQQGQLG
LSSGETDFRLLEESIANLNRSTSRPENPKSSTPAAGCATPTEKEFPQTHSDPSSEQQNRK
SQPGTNGGSVKLYTTDQSTFDILQDLEFSAGSPGKETNESPWRSDLLIDENLLSPLAGED
DPFLLEGDVNEDCKPLILPDTKPKIQDTGDTILSSPSSVALPQVKTEKDDFIELCTPGVI
KQEKLGPVYCQASFSGTNIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPVFN
VIPPIPVGSENWNRCQGSGEDNLTSLGAMNFAGRSVFSNGYSSPGMRPDVSSPPSSSSTA
TGPPPKLCLVCSDEASVCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNC
PACRYRKCLQAGMNLEARKTKKKIKGIQQATAGVSQDTSENANKTIVPAALPQLTPTLVS
LLEVIEPEVLYAGYDSSVPDSAWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMT
LLQYSWMFLMAFALGWRSYRQASGNLLCFAPDLIINEQRMTLPCMYDQCKHMLFISTELQ
RLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQR
FYQLTKLLDSMHDVVENLLSYCFQTFLDKSMSIEFPEMLAEIITNQIPKYSNGNIKKLLF
HQK
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| BDBM50041896 |
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| n/a |
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| Name | BDBM50041896 |
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| Synonyms: | CHEMBL3358954 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25F4N3O4S |
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| Mol. Mass. | 515.521 |
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| SMILES | CCS(=O)(=O)c1cc2cc(C[C@](O)(CC(C)(C)c3ccc(F)cc3C(N)=O)C(F)(F)F)[nH]c2cn1 |r| |
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| Structure | 
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